Gene Therapy of Pancreatic Cancer With Green Fluorescent Protein and Tumor Necrosis Factor–Related Apoptosis-Inducing Ligand Fusion Gene Expression Driven by a Human Telomerase Reverse Transcriptase Promoter

被引：0

作者：

Matthew H. Katz

Daniel E. Spivack

Shinako Takimoto

Bingliang Fang

Douglas W. Burton

A. R. Moossa

Robert M. Hoffman

Michael Bouvet

机构：

[1] University of California at San Diego,Department of Surgery

[2] University of California at San Diego,Department of Medicine

[3] University of Texas M. D. Anderson Cancer Center,Department of Cardiovascular and Thoracic Surgery

[4] AntiCancer,Department of Surgery

[5] Inc.,undefined

[6] University of California,undefined

来源：

Annals of Surgical Oncology | 2003年 / 10卷

关键词：

Pancreatic cancer; Gene therapy; TRAIL; GFP; RFP;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Background: Tumor necrosis factor–related apoptosis-inducing ligand (TRAIL) induces apoptosis in malignant cells but not in normal cells. Ad/g-TRAIL, an adenoviral vector in which expression of green fluorescent protein (GFP) and TRAIL is driven by a human telomerase reverse transcriptase promoter, has shown promise as a targeted antitumor agent.

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