Gene Therapy of Pancreatic Cancer With Green Fluorescent Protein and Tumor Necrosis Factor–Related Apoptosis-Inducing Ligand Fusion Gene Expression Driven by a Human Telomerase Reverse Transcriptase Promoter

被引：0
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作者：
Matthew H. Katz
Daniel E. Spivack
Shinako Takimoto
Bingliang Fang
Douglas W. Burton
A. R. Moossa
Robert M. Hoffman
Michael Bouvet
机构：
[1] University of California at San Diego,Department of Surgery
[2] University of California at San Diego,Department of Medicine
[3] University of Texas M. D. Anderson Cancer Center,Department of Cardiovascular and Thoracic Surgery
[4] AntiCancer,Department of Surgery
[5] Inc.,undefined
[6] University of California,undefined
来源：
Annals of Surgical Oncology | 2003年 / 10卷
关键词：
Pancreatic cancer; Gene therapy; TRAIL; GFP; RFP;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Background: Tumor necrosis factor–related apoptosis-inducing ligand (TRAIL) induces apoptosis in malignant cells but not in normal cells. Ad/g-TRAIL, an adenoviral vector in which expression of green fluorescent protein (GFP) and TRAIL is driven by a human telomerase reverse transcriptase promoter, has shown promise as a targeted antitumor agent.
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