Gene Therapy of Pancreatic Cancer With Green Fluorescent Protein and Tumor Necrosis Factor–Related Apoptosis-Inducing Ligand Fusion Gene Expression Driven by a Human Telomerase Reverse Transcriptase Promoter

被引：0
|
作者：
Matthew H. Katz
Daniel E. Spivack
Shinako Takimoto
Bingliang Fang
Douglas W. Burton
A. R. Moossa
Robert M. Hoffman
Michael Bouvet
机构：
[1] University of California at San Diego,Department of Surgery
[2] University of California at San Diego,Department of Medicine
[3] University of Texas M. D. Anderson Cancer Center,Department of Cardiovascular and Thoracic Surgery
[4] AntiCancer,Department of Surgery
[5] Inc.,undefined
[6] University of California,undefined
来源：
Annals of Surgical Oncology | 2003年 / 10卷
关键词：
Pancreatic cancer; Gene therapy; TRAIL; GFP; RFP;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Background: Tumor necrosis factor–related apoptosis-inducing ligand (TRAIL) induces apoptosis in malignant cells but not in normal cells. Ad/g-TRAIL, an adenoviral vector in which expression of green fluorescent protein (GFP) and TRAIL is driven by a human telomerase reverse transcriptase promoter, has shown promise as a targeted antitumor agent.
引用
收藏
相关论文
共 50 条
  • [1] Gene therapy of pancreatic cancer with green fluorescent protein and tumor necrosis factor-related apoptosis-inducing ligand fusion gene expression driven by a human telomerase reverse transcriptase promoter
    Katz, MH
    Spivack, DE
    Takimoto, S
    Fang, BL
    Burton, DW
    Moossa, AR
    Hoffman, RM
    Bouvet, M
    ANNALS OF SURGICAL ONCOLOGY, 2003, 10 (07) : 762 - 772
  • [2] Targeted expression of green fluorescent protein/tumor necrosis factor-related apoptosis-inducing ligand fusion protein from human telomerase reverse transcriptase promoter elicits antitumor activity without toxic effects on primary human hepatocytes
    Lin, TY
    Gu, J
    Zhang, LD
    Huang, XF
    Stephens, LC
    Curley, SA
    Fang, BL
    CANCER RESEARCH, 2002, 62 (13) : 3620 - 3625
  • [3] Fiber-modified adenoviral vector expressing the tumor necrosis factor-related apoptosis-inducing ligand gene from the human telomerase reverse transcriptase promoter induces apoptosis in human hepatocellular carcinoma cells
    Jacob, Dietmar
    Schumacher, Guido
    Bahra, Marcus
    Davis, John
    Zhu, Hong-Bo
    Zhang, Li-Dong
    Teraishi, Fuminori
    Neuhaus, Peter
    Fang, Bing-Liang
    WORLD JOURNAL OF GASTROENTEROLOGY, 2005, 11 (17) : 2552 - 2556
  • [4] Fiber-modified adenoviral vector expressing the tumor necrosis factor-related apoptosis-inducing ligand gene from the human telomerase reverse transcriptase promoter induces apoptosis in human hepatocellular carcinoma cells
    Dietmar Jacob
    Guido Schumacher
    Marcus Bahra
    John Davis
    Fuminori Teraishi
    Peter Neuhaus
    World Journal of Gastroenterology, 2005, (17) : 2552 - 2556
  • [5] Enforced expression of a truncated form of Bax-α (tBax) driven by human telomerase reverse transcriptase (hTERT) promoter sensitizes tumor cells to chemotherapeutic agents or tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)
    Toyota, H
    Kondo, S
    Kyo, S
    Mizuguchi, J
    ANTICANCER RESEARCH, 2006, 26 (1A) : 99 - 105
  • [6] Tumor necrosis factor-related apoptosis-inducing ligand and its receptor expression and the pathway of apoptosis in human pancreatic cancer
    Satoh, K
    Kaneko, K
    Hirota, M
    Masamune, A
    Satoh, A
    Shimosegawa, T
    PANCREAS, 2001, 23 (03) : 251 - 258
  • [7] Tumor necrosis factor-related apoptosis-inducing ligand induces apoptosis and inflammatory gene expression in human endothelial cells
    Li, JH
    Kirkiles-Smith, NC
    McNiff, JM
    Pober, JS
    FASEB JOURNAL, 2003, 17 (07): : C136 - C136
  • [8] Viral transfer of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) in gene therapy
    Wedrowska, Ewelina
    Wandtke, Tomasz
    Dyczek, Andrzej
    Wozniak, Joanna
    POSTEPY HIGIENY I MEDYCYNY DOSWIADCZALNEJ, 2015, 69 : 1411 - 1422
  • [9] Targeted gene therapy of pancreatic cancer cells with TRAIL and a human telomerase reverse transcriptase promoter
    Katz, MH
    Takimoto, S
    Spivack, DE
    Nassirpour, R
    Fang, B
    Moossa, AR
    Hoffman, RM
    Bouvet, M
    ANNALS OF SURGICAL ONCOLOGY, 2003, 10 (01) : S13 - S13
  • [10] Radioresponsive tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) gene therapy for malignant brain tumors
    H Tsurushima
    X Yuan
    L E Dillehay
    K W Leong
    Cancer Gene Therapy, 2007, 14 : 706 - 716
12345