Pharmacokinetic modeling of [11C]flumazenil kinetics in the rat brain

被引：0
|
作者：
Isadora Lopes Alves
David Vállez García
Andrea Parente
Janine Doorduin
Rudi Dierckx
Ana Maria Marques da Silva
Michel Koole
Antoon Willemsen
Ronald Boellaard
机构：
[1] University of Groningen,Department of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen
[2] Pontifícia Universidade Católica do Rio Grande do Sul,Laboratory of Medical Imaging, School of Physics
[3] KU Leuven,Department of Nuclear Medicine and Molecular Imaging
来源：
EJNMMI Research | / 7卷
关键词：
[; C]Flumazenil; Pharmacokinetic modeling; Rat; GABA; receptors; PET;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
引用
收藏
相关论文
共 50 条
  • [31] Tiagabine Increases [11C] flumazenil Binding in Cortical Brain Regions in Healthy Control Subjects
    Frankle, W. Gordon
    Cho, Raymond Y.
    Narendran, Rajesh
    Mason, N. Scott
    Vora, Shivangi
    Litschge, Maralee
    Price, Julie C.
    Lewis, David A.
    Mathis, Chester A.
    NEUROPSYCHOPHARMACOLOGY, 2009, 34 (03) : 624 - 633
  • [32] Tiagabine Increases [11C]flumazenil Binding in Cortical Brain Regions in Healthy Control Subjects
    W Gordon Frankle
    Raymond Y Cho
    Rajesh Narendran
    N Scott Mason
    Shivangi Vora
    Maralee Litschge
    Julie C Price
    David A Lewis
    Chester A Mathis
    Neuropsychopharmacology, 2009, 34 : 624 - 633
  • [33] [11C]Flumazenil metabolite measurement in plasma is not necessary for accurate brain benzodiazepine receptor quantification
    Sandra M. Sanabria-Bohórquez
    Daniel Labar
    Philippe Levêque
    Anne Bol
    Anne G. De Volder
    Christian Michel
    Claude Veraart
    European Journal of Nuclear Medicine, 2000, 27 : 1674 - 1683
  • [34] Reduced [11C]flumazenil radioligand binding in the thalamus in alcoholics
    Neiman, J
    Litton, JE
    ADDICTION BIOLOGY, 2000, 5 (01) : 97 - 99
  • [35] [11C]flumazenil PET in patients with epilepsy with dual pathology
    Juhasz, C
    Nagy, F
    Muzik, O
    Watson, C
    Shah, J
    Chugani, HT
    EPILEPSIA, 1999, 40 (05) : 566 - 574
  • [36] Parametric images of [11C]Flumazenil binding: Comparison of methods
    Klumpers, Ursula
    Boellaard, R.
    Veltman, D.
    Kloet, R.
    Comans, E.
    Hoogendijk, W.
    Lammertsma, A.
    NEUROIMAGE, 2006, 31 : T76 - T76
  • [37] [11C]Raclopride kinetics in awake and anesthetized rats using the RatCAP awake rat brain PET
    Schulz, Daniela
    Southekal, Sudeepti
    Junnarkar, Sachin
    Maramraju, Harsha
    Schiffer, Wynne
    Krishnamoorthy, Srilalan
    Purschke, Martin
    Vaska, Paul
    Woody, Craig
    Schlyer, David
    JOURNAL OF NUCLEAR MEDICINE, 2009, 50
  • [38] Pharmacokinetic modeling of P-glycoprotein function at the rat and human blood–brain barriers studied with (R)-[11C]verapamil positron emission tomography
    Julia Müllauer
    Claudia Kuntner
    Martin Bauer
    Jens P Bankstahl
    Markus Müller
    Rob A Voskuyl
    Oliver Langer
    Stina Syvänen
    EJNMMI Research, 2
  • [39] [11C]Flumazenil brain uptake is influenced by the blood-brain barrier efflux transporter P-glycoprotein
    Froklage, Femke E.
    Syvanen, Stina
    Hendrikse, N. Harry
    Huisman, Marc C.
    Molthoff, Carla Fm
    Tagawa, Yoshihiko
    Reijneveld, Jaap C.
    Heimans, Jan J.
    Lammertsma, Adriaan A.
    Eriksson, Jonas
    De lange, Elizabeth C. M.
    Voskuyl, Rob A.
    EJNMMI RESEARCH, 2012, 2
  • [40] [11C]Flumazenil brain uptake is influenced by the blood-brain barrier efflux transporter P-glycoprotein
    Femke E Froklage
    Stina Syvänen
    N Harry Hendrikse
    Marc C Huisman
    Carla FM Molthoff
    Yoshihiko Tagawa
    Jaap C Reijneveld
    Jan J Heimans
    Adriaan A Lammertsma
    Jonas Eriksson
    Elizabeth CM de Lange
    Rob A Voskuyl
    EJNMMI Research, 2
12345