Pharmacokinetic modeling of [11C]flumazenil kinetics in the rat brain

被引：0
|
作者：
Isadora Lopes Alves
David Vállez García
Andrea Parente
Janine Doorduin
Rudi Dierckx
Ana Maria Marques da Silva
Michel Koole
Antoon Willemsen
Ronald Boellaard
机构：
[1] University of Groningen,Department of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen
[2] Pontifícia Universidade Católica do Rio Grande do Sul,Laboratory of Medical Imaging, School of Physics
[3] KU Leuven,Department of Nuclear Medicine and Molecular Imaging
来源：
EJNMMI Research | / 7卷
关键词：
[; C]Flumazenil; Pharmacokinetic modeling; Rat; GABA; receptors; PET;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
引用
收藏
相关论文
共 50 条
  • [21] Pharmacokinetic Modeling of [11C]GSK-189254, PET Tracer Targeting H3 Receptors, in Rat Brain
    Ghazanfari, Nafiseh
    van Waarde, Aren
    Doorduin, Janine
    Sijbesma, Jurgen W. A.
    Kominia, Maria
    Koelewijn, Martin
    Attia, Khaled
    Willemsen, Antoon T. M.
    Visser, Ton J.
    Heeres, Andre
    Dierckx, Rudi A. J. O.
    de Vries, Erik F. J.
    Elsinga, Philip H.
    MOLECULAR PHARMACEUTICS, 2022, 19 (03) : 918 - 928
  • [22] A preliminary PET comparison of [18F]flumazenil and [11C]flumazenil
    Krasikova, RN
    Seneca, N
    Ryzhikov, NN
    Gomzina, NA
    Fedorova, OS
    Shchukin, E
    Gulyas, B
    Hall, H
    Savic, I
    Halldin, C
    NEUROIMAGE, 2004, 22 : T152 - T152
  • [23] Comparison of [11C]Flumazenil and glucose PET abnormalities in patients with epilepsy and brain lesions
    Juhasz, C
    da Silva, EA
    Watson, CE
    Muzik, O
    Shah, J
    Chugani, DC
    von Stockhausen, HM
    Chugani, HT
    NEUROLOGY, 1999, 52 (06) : A58 - A58
  • [24] Use of Potassium tert-Butoxide in the Synthesis of [11C]Flumazenil, [11C]PK11195 and [11C]-(+)-DTBZ
    Garcia-Arguello, S. F.
    EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2015, 42 : S480 - S481
  • [25] Contribution of activated microglia to changes in [11C]flumazenil binding in the rat brain. Evaluation of pons as reference tissue
    Parente, A.
    Shoji, A.
    Garcia, D. Vallez
    Maas, B.
    Zijlma, R.
    Dierckx, R. A. J. O.
    de Vries, E. F. J.
    Doorduin, J.
    EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2014, 41 : S453 - S453
  • [26] Parametric methods for quantification of [11C]Flumazenil studies
    Klumpers, Ursula M. H.
    Boellaard, Ronald
    Veltman, Dick J.
    Kloet, Reina W.
    Hoogendijk, Witte J. G.
    Lammertsma, Adriaan A.
    NEUROIMAGE, 2010, 52 : S189 - S189
  • [27] A microPET comparison of the effects of etifoxine and diazepam on [11C]flumazenil uptake in rat brains
    Bouillot, Caroline
    Bonnefoi, Frederic
    Liger, Francois
    Zimmer, Luc
    NEUROSCIENCE LETTERS, 2016, 612 : 74 - 79
  • [28] Radiosynthesis of [11C]Flumazenil and [11C]Deprenyl using a fully automated iMiDEV microfluidic radiosynthesizer
    Chandrashekara, H. Mallapura
    Tanguy, L.
    Langstrom, B.
    Le Meunier, L.
    Halldin, C.
    Nag, S.
    EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2021, 48 (SUPPL 1) : S223 - S224
  • [29] Kinetic modeling of [11C]sertraline in human brain
    Kim, Ji Who
    Lee, Jae Sung
    Kim, Su Jin
    Hoigebazar, Lathika
    Lee, Hak Jeong
    Shin, Kwang-Hee
    Yu, Kyung-Sang
    Ahn, Wonsik
    Jeong, Jae
    Lee, Dong Soo
    JOURNAL OF NUCLEAR MEDICINE, 2010, 51
  • [30] [11C]flumazenil metabolite measurement in plasma is not necessary for accurate brain benzodiazepine receptor quantification
    Sanabria-Bohórquez, SM
    Labar, D
    Levêque, P
    Bol, A
    De Volder, AG
    Michel, C
    Veraart, C
    EUROPEAN JOURNAL OF NUCLEAR MEDICINE, 2000, 27 (11) : 1674 - 1683
12345