Oncogenic role of dysregulated leptin signaling in the pathogenesis of ovarian cancer

被引：0
|
作者：
Iman W. Achkar
Ajaz A. Bhat
Maria Zafar
Madiha Abbas
Omar S. Khan
Shilpa Kuttikrishnan
Kirti S. Prabhu
Shahab Uddin
机构：
[1] Hamad Medical Corporation,Translational Research Institute, Academic Health System
[2] Sidra Medicine,Department of Biochemistry
[3] Research Branch,undefined
[4] Aligarh Muslim University,undefined
[5] University of Illinois at Chicago,undefined
来源：
Translational Medicine Communications | / 4卷 / 1期
关键词：
Leptin; Ob-R; PI3K/AKT pathway; Ovarian Cancer;
D O I：
10.1186/s41231-018-0031-2
中图分类号：
学科分类号：
摘要：
Leptin, a pleiotropic hormone is produced by adipose tissues and plays a critical role in various biological functions. Leptin mediates its function through interaction with specific receptors. The leptin-receptor interaction modulates activation of a number of signaling pathways, such as JAK-STAT, PI3-Kinase-AKT and MAP kinases. Recently, deregulated leptin-mediated signaling has been shown in many cancers including ovarian cancer. A number of studies have shown a link between obesity and carcinogenesis of different cancers via leptin deregulated signaling pathways. In this review, we highlighted the role of deregulated leptin receptor-mediated signaling in the etiology of ovarian cancer.
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