Oncogenic role of dysregulated leptin signaling in the pathogenesis of ovarian cancer

被引：0
|
作者：
Iman W. Achkar
Ajaz A. Bhat
Maria Zafar
Madiha Abbas
Omar S. Khan
Shilpa Kuttikrishnan
Kirti S. Prabhu
Shahab Uddin
机构：
[1] Hamad Medical Corporation,Translational Research Institute, Academic Health System
[2] Sidra Medicine,Department of Biochemistry
[3] Research Branch,undefined
[4] Aligarh Muslim University,undefined
[5] University of Illinois at Chicago,undefined
来源：
Translational Medicine Communications | / 4卷 / 1期
关键词：
Leptin; Ob-R; PI3K/AKT pathway; Ovarian Cancer;
D O I：
10.1186/s41231-018-0031-2
中图分类号：
学科分类号：
摘要：
Leptin, a pleiotropic hormone is produced by adipose tissues and plays a critical role in various biological functions. Leptin mediates its function through interaction with specific receptors. The leptin-receptor interaction modulates activation of a number of signaling pathways, such as JAK-STAT, PI3-Kinase-AKT and MAP kinases. Recently, deregulated leptin-mediated signaling has been shown in many cancers including ovarian cancer. A number of studies have shown a link between obesity and carcinogenesis of different cancers via leptin deregulated signaling pathways. In this review, we highlighted the role of deregulated leptin receptor-mediated signaling in the etiology of ovarian cancer.
引用
收藏
相关论文
共 50 条
  • [21] Updates of the role of oxidative stress in the pathogenesis of ovarian cancer
    Saed, Ghassan M.
    Diamond, Michael P.
    Fletcher, Nicole M.
    GYNECOLOGIC ONCOLOGY, 2017, 145 (03) : 595 - 602
  • [22] The oncogenic role of Jagged1/Notch signaling in cancer
    Xiu, Meng-xi
    Liu, Yuan-meng
    Kuang, Bo-hai
    BIOMEDICINE & PHARMACOTHERAPY, 2020, 129
  • [23] Role of Notch and its oncogenic signaling crosstalk in breast cancer
    Guo, Shanchun
    Liu, Mingli
    Gonzalez-Perez, Ruben R.
    BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER, 2011, 1815 (02): : 197 - 213
  • [24] Melatonin changes energy metabolism and reduces oncogenic signaling in ovarian cancer cells
    Silveira, Henrique Spaulonci
    Cesario, Roberta Carvalho
    Vigaroa, Renan Aparecido
    Gaiotte, Leticia Barbosa
    Cucielo, Maira Smaniotto
    Guimaraes, Fernando
    Seiva, Fabio Rodrigues Ferreira
    Zuccari, Debora Aparecida P. C.
    Reiter, Russel J.
    de Almeida Chuffa, Luiz Gustavo
    MOLECULAR AND CELLULAR ENDOCRINOLOGY, 2024, 592
  • [25] Resveratrol Targets a Variety of Oncogenic and Oncosuppressive Signaling for Ovarian Cancer Prevention and Treatment
    Xu, Xue-Ling
    Deng, Shou-Long
    Lian, Zheng-Xing
    Yu, Kun
    ANTIOXIDANTS, 2021, 10 (11)
  • [26] The Role of Androgen Receptor Signaling in Ovarian Cancer
    Mizushima, Taichi
    Miyamoto, Hiroshi
    CELLS, 2019, 8 (02)
  • [27] A study on oncogenic role of leptin and leptin receptor in oral squamous cell
    Hussain, Syed Rizwan
    Naqvi, Hena
    Gupta, Shalini
    Mahdi, Abbas Ali
    Kumari, Pratibha
    Waseem, Mohammad
    Ahmad, Mohammad Kaleem
    TUMOR BIOLOGY, 2015, 36 (08) : 6515 - 6523
  • [28] EphrinB1 expression is dysregulated and promotes oncogenic signaling in medulloblastoma
    Nicole McKinney
    Liangping Yuan
    Hongying Zhang
    Jingbo Liu
    Yoon-Jae Cho
    Elisabeth Rushing
    Matthew Schniederjan
    Tobey J. MacDonald
    Journal of Neuro-Oncology, 2015, 121 : 109 - 118
  • [29] EphrinB1 expression is dysregulated and promotes oncogenic signaling in medulloblastoma
    McKinney, Nicole
    Yuan, Liangping
    Zhang, Hongying
    Liu, Jingbo
    Cho, Yoon-Jae
    Rushing, Elisabeth
    Schniederjan, Matthew
    MacDonald, Tobey J.
    JOURNAL OF NEURO-ONCOLOGY, 2015, 121 (01) : 109 - 118
  • [30] METTL3 serves an oncogenic role in human ovarian cancer cells partially via the AKT signaling pathway
    Liang, Shumei
    Guan, Hongwei
    Lin, Xiaoyan
    Li, Na
    Geng, Feng
    Li, Juan
    ONCOLOGY LETTERS, 2020, 19 (04) : 3197 - 3204
12345