AIEgen based light-up probes for live cell imaging

被引：0

作者：

Jing Liang

Guangxue Feng

Ryan Tsz Kin Kwok

Dan Ding

Benzhong Tang

Bin Liu

机构：

[1] National University of Singapore,Department of Chemical and Biomolecular Engineering

[2] National University of Singapore,NUS Environmental Research Institute

[3] Division of Biomedical Engineering,Department of Chemistry

[4] the Hong Kong University of Science and Technology,SCUT

[5] Guangdong Innovative Research Team,HKUST Joint Research Laboratory

[6] State Key Laboratory of Luminescent Materials and Devices,Institute of Materials Research Engineering

[7] South China University of Technology,undefined

[8] Agency for Science,undefined

[9] Technology and Research,undefined

来源：

Science China Chemistry | 2016年 / 59卷

关键词：

aggregation-induced emission (AIE); light-up probe; live cell imaging; nucleus imaging; targeted cell imaging; AIE probes;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Fluorescent light-up probes comprising a tetraphenylethene unit with aggregation-induced emission (AIE) characteristics and a water-soluble peptide have been designed and synthesized which provide cell membrane and nuclear permeability to live cells. This strategy has offered new opportunities for the development of probes with light-up ability and good signal-to-noise ratio. The selectivity or targeting specificity is determined by the peptide sequence, i.e. a nuclear localization signal that leads to nucleus imaging and a cell biomarker targeting peptide that offers specific light-up imaging of HT-29 cells.

引用

页码：53 / 61

页数：8

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