Effect of hyperprolinemia on acetylcholinesterase and butyrylcholinesterase activities in rat

被引:0
|
作者
D. Delwing
F. Chiarani
C. M. D. Wannmacher
M. Wajner
A. T. S. Wyse
机构
[1] ICBS,Departamento de Bioquímica
[2] Universidade Federal do Rio Grande do Sul,undefined
来源
Amino Acids | 2005年 / 28卷
关键词
Keywords: Hyperprolinemia type II   Proline   Acetylcholinesterase   Butyrylcholinesterase   Experimental model;
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学科分类号
摘要
We observed here that acute proline (Pro) administration provoked a decrease (32%) of acetylcholinesterase (AChE) activity in cerebral cortex and an increase (22%) of butyrylcholinesterase (BuChE) activity in the serum of 29-day-old rats. In contrast, chronic administration of Pro did not alter AChE or BuChE activities. Furthermore, pretreatment of rats with vitamins E and C combined or alone, Nϖ-nitro-L-arginine methyl ester or melatonin prevented the reduction of AChE activity caused by acute Pro administration, suggesting the participation of oxidative stress in such effects.
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收藏
页码:305 / 308
页数:3
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