Effect of hyperprolinemia on acetylcholinesterase and butyrylcholinesterase activities in rat

被引：0

作者：

D. Delwing

F. Chiarani

C. M. D. Wannmacher

M. Wajner

A. T. S. Wyse

机构：

[1] ICBS,Departamento de Bioquímica

[2] Universidade Federal do Rio Grande do Sul,undefined

来源：

Amino Acids | 2005年 / 28卷

关键词：

Keywords: Hyperprolinemia type II Proline Acetylcholinesterase Butyrylcholinesterase Experimental model;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

We observed here that acute proline (Pro) administration provoked a decrease (32%) of acetylcholinesterase (AChE) activity in cerebral cortex and an increase (22%) of butyrylcholinesterase (BuChE) activity in the serum of 29-day-old rats. In contrast, chronic administration of Pro did not alter AChE or BuChE activities. Furthermore, pretreatment of rats with vitamins E and C combined or alone, Nϖ-nitro-L-arginine methyl ester or melatonin prevented the reduction of AChE activity caused by acute Pro administration, suggesting the participation of oxidative stress in such effects.

引用

页码：305 / 308

页数：3

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