Induced pluripotent stem cell technology: a decade of progress

被引：0
|
作者：
Yanhong Shi
Haruhisa Inoue
Joseph C. Wu
Shinya Yamanaka
机构：
[1] Beckman Research Institute of City of Hope,Division of Stem Cell Biology Research, Department of Developmental and Stem Cell Biology
[2] Center for iPS Cell Research and Application (CiRA),undefined
[3] Kyoto University,undefined
[4] Stanford Cardiovascular Institute,undefined
[5] Gladstone Institute of Cardiovascular Disease,undefined
来源：
Nature Reviews Drug Discovery | 2017年 / 16卷
关键词：
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Human induced pluripotent stem cell (iPSC) technology has evolved rapidly since its inception in 2007.Human iPSC technology has been widely used for disease modelling; for example, for neurodegenerative and psychiatric disorders.Human iPSC technology has yielded several drug candidates that are currently in clinical trials.The first clinical trial using human iPSC-derived products has been initiated for age-related macular degeneration.The combination with gene editing and 3D organoid technologies makes the iPSC platform more powerful.The continued development of iPSC technology and its integration with other technologies has the potential to make substantial contributions to disease modelling, drug discovery and regenerative medicine.
引用
收藏
页码：115 / 130
页数：15
相关论文
共 50 条
  • [41] Progress of Induced Pluripotent Stem Cell-Derived Renal Organoids in Clinical Application
    Ning, Na
    Liu, Zhiting
    Li, Xinyu
    Liu, Yi
    Song, Wei
    KIDNEY DISEASES, 2024,
  • [42] Dendritic Cell Differentiation from Human Induced Pluripotent Stem Cells: Challenges and Progress
    Oliveira, Nelio A. J.
    Sevim, Handan
    STEM CELLS AND DEVELOPMENT, 2022, 31 (9-10) : 207 - 220
  • [43] Induced pluripotent stem cell overview
    Chu, Vi
    Genetic Engineering and Biotechnology News, 2010, 30 (04):
  • [44] Progress and Prospects of Human Pluripotent Stem Cell Research
    Xu, Chunhui
    CURRENT STEM CELL RESEARCH & THERAPY, 2010, 5 (03) : 205 - 206
  • [45] Recent progress in induced pluripotent stem cell-derived cardiac cell sheets for tissue engineering
    Gao, Botao
    Matsuura, Katsuhisa
    Shimizu, Tatsuya
    BIOSCIENCE TRENDS, 2019, 13 (04) : 292 - 298
  • [46] Induced Pluripotent Stem Cell Consensus Genes: Implication for the Risk of Tumorigenesis and Cancers in Induced Pluripotent Stem Cell Therapy
    Zhang, Gaochuan
    Shang, Bingxue
    Yang, Ping
    Cao, Zhifei
    Pan, Yanyan
    Zhou, Quansheng
    STEM CELLS AND DEVELOPMENT, 2012, 21 (06) : 955 - 964
  • [47] Recapitulating Long-QT Syndrome Using Induced Pluripotent Stem Cell Technology
    Dirschinger, Ralf J.
    Goedel, Alexander
    Moretti, Alessandra
    Laugwitz, Karl-Ludwig
    Sinnecker, Daniel
    PEDIATRIC CARDIOLOGY, 2012, 33 (06) : 950 - 958
  • [48] Evaluation of Redox Dysregulation in the Pathology of Schizophrenia Using Induced Pluripotent Stem Cell Technology
    Giangreco, Basilio
    Steullet, Pascal
    Cabungcal, Jan-Harry
    Bartesaghi, Luca
    Toni, Nicolas
    Chrast, Roman
    Do, Kim Q.
    BIOLOGICAL PSYCHIATRY, 2014, 75 (09) : 186S - 186S
  • [49] Recapitulating Long-QT Syndrome Using Induced Pluripotent Stem Cell Technology
    Ralf J. Dirschinger
    Alexander Goedel
    Alessandra Moretti
    Karl-Ludwig Laugwitz
    Daniel Sinnecker
    Pediatric Cardiology, 2012, 33 : 950 - 958
  • [50] Induced pluripotent stem cell technology for spinal cord injury: a promising alternative therapy
    Li, Yu
    Shen, Ping-Ping
    Wang, Bin
    NEURAL REGENERATION RESEARCH, 2021, 16 (08) : 1500 - 1509
12345