Induced pluripotent stem cell technology: a decade of progress

被引：0
|
作者：
Yanhong Shi
Haruhisa Inoue
Joseph C. Wu
Shinya Yamanaka
机构：
[1] Beckman Research Institute of City of Hope,Division of Stem Cell Biology Research, Department of Developmental and Stem Cell Biology
[2] Center for iPS Cell Research and Application (CiRA),undefined
[3] Kyoto University,undefined
[4] Stanford Cardiovascular Institute,undefined
[5] Gladstone Institute of Cardiovascular Disease,undefined
来源：
Nature Reviews Drug Discovery | 2017年 / 16卷
关键词：
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Human induced pluripotent stem cell (iPSC) technology has evolved rapidly since its inception in 2007.Human iPSC technology has been widely used for disease modelling; for example, for neurodegenerative and psychiatric disorders.Human iPSC technology has yielded several drug candidates that are currently in clinical trials.The first clinical trial using human iPSC-derived products has been initiated for age-related macular degeneration.The combination with gene editing and 3D organoid technologies makes the iPSC platform more powerful.The continued development of iPSC technology and its integration with other technologies has the potential to make substantial contributions to disease modelling, drug discovery and regenerative medicine.
引用
收藏
页码：115 / 130
页数：15
相关论文
共 50 条
  • [21] Accelerating progress in induced pluripotent stem cell research for neurological diseases
    Ito, Daisuke
    Okano, Hideyuki
    Suzuki, Norihiro
    ANNALS OF NEUROLOGY, 2012, 72 (02) : 167 - 174
  • [22] Application of induced pluripotent stem cell and embryonic stem cell technology to the study of male infertility
    Mahabadi, Javad Amini
    Sabzalipour, Hamed
    Bafrani, Hassan Hassani
    Hayat, Seyed Mohammad Gheibi
    Nikzad, Hossein
    JOURNAL OF CELLULAR PHYSIOLOGY, 2018, 233 (11) : 8441 - 8449
  • [23] An Autism Stem Cell Biorepository: Gaining Insights from Induced Pluripotent Stem Cell Technology
    Schwartz, Philip H.
    Brick, David J.
    Stover, Alexander E.
    Hagerman, Randi J.
    Ono, Michele Y.
    Hessl, David R.
    Ngotran, Lily
    Nethercott, Hubert E.
    Tassone, Flora
    NEUROLOGY, 2011, 76 (09) : A373 - A373
  • [24] Induced pluripotent stem cell technology: Toward the future of cardiac arrhythmias
    Gnecchi, Massimiliano
    Stefanello, Manuela
    Mura, Manuela
    INTERNATIONAL JOURNAL OF CARDIOLOGY, 2017, 237 : 49 - 52
  • [25] Advancements in Induced Pluripotent Stem Cell Technology for Cardiac Regenerative Medicine
    Suh, Carol Y.
    Wang, Zelun
    Bartulos, Oscar
    Qyang, Yibing
    JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS, 2014, 19 (04) : 330 - 339
  • [26] Application of Induced Pluripotent Stem Cell Technology to the Study of Hematological Diseases
    Li, Mailin
    Cascino, Pasquale
    Ummarino, Simone
    Di Ruscio, Annalisa
    CELLS, 2017, 6 (01)
  • [27] Induced pluripotent stem cell technology for modelling and therapy of cerebellar ataxia
    Watson, Lauren M.
    Wong, Maggie M. K.
    Becker, Esther B. E.
    OPEN BIOLOGY, 2015, 5 (07):
  • [28] Induced pluripotent stem cells are induced pluripotent stem cell-like cells
    Liting Song
    Emanuel Goldman
    The Journal of Biomedical Research, 2015, 29 (01) : 1 - 2
  • [29] Induced pluripotent stem cells are induced pluripotent stem cell-like cells
    Song, Liting
    Goldman, Emanuel
    JOURNAL OF BIOMEDICAL RESEARCH, 2015, 29 (01): : 1 - 2
  • [30] Induced pluripotent stem cells are induced pluripotent stem cell-like cells
    Liting Song
    Emanuel Goldman
    The Journal of Biomedical Research, 2015, (01) : 1 - 2
12345