Induced pluripotent stem cell technology: a decade of progress

被引：0
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作者：
Yanhong Shi
Haruhisa Inoue
Joseph C. Wu
Shinya Yamanaka
机构：
[1] Beckman Research Institute of City of Hope,Division of Stem Cell Biology Research, Department of Developmental and Stem Cell Biology
[2] Center for iPS Cell Research and Application (CiRA),undefined
[3] Kyoto University,undefined
[4] Stanford Cardiovascular Institute,undefined
[5] Gladstone Institute of Cardiovascular Disease,undefined
来源：
Nature Reviews Drug Discovery | 2017年 / 16卷
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摘要：
Human induced pluripotent stem cell (iPSC) technology has evolved rapidly since its inception in 2007.Human iPSC technology has been widely used for disease modelling; for example, for neurodegenerative and psychiatric disorders.Human iPSC technology has yielded several drug candidates that are currently in clinical trials.The first clinical trial using human iPSC-derived products has been initiated for age-related macular degeneration.The combination with gene editing and 3D organoid technologies makes the iPSC platform more powerful.The continued development of iPSC technology and its integration with other technologies has the potential to make substantial contributions to disease modelling, drug discovery and regenerative medicine.
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页码：115 / 130
页数：15
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