SIRT1 regulates the histone methyl-transferase SUV39H1 during heterochromatin formation

被引：0
|
作者：
Alejandro Vaquero
Michael Scher
Hediye Erdjument-Bromage
Paul Tempst
Lourdes Serrano
Danny Reinberg
机构：
[1] Howard Hughes Medical Institute,Division of Nucleic Acids Enzymology, Department of Biochemistry
[2] University of Medicine and Dentistry of New Jersey,Department of Genetics
[3] Robert Wood Johnson Medical School,Department of Biochemistry
[4] Human Genetics Institute,undefined
[5] Rutgers University,undefined
[6] 145 Bevier Road,undefined
[7] Piscataway,undefined
[8] New Jersey 08854,undefined
[9] USA,undefined
[10] NYU-Medical School,undefined
[11] 522 First Avenue,undefined
[12] New York,undefined
[13] New York 10016,undefined
[14] USA,undefined
[15] Molecular Biology Program,undefined
[16] Memorial Sloan Kettering Cancer Center,undefined
[17] 1275 York Avenue,undefined
[18] New York,undefined
[19] New York 10021,undefined
[20] USA ,undefined
[21] Present address: ICREA and IBMB-CSIC/IRB,undefined
[22] Parc Cientific de Barcelona,undefined
[23] Josep Samitier 1–5,undefined
[24] 08028 Barcelona,undefined
[25] Spain.,undefined
来源：
Nature | 2007年 / 450卷
关键词：
D O I：
暂无
中图分类号：
学科分类号：
摘要：
SUV39H1 is the major methyltransferase responsible for tri-methylation of histone H3 at lysine 9 in heterochromatin. The histone deacetylase SIRT1 is shown to target the SUV39H1 enzyme and contribute to elevated levels of SUV39H1 activity and H3K9me3 in heterochromatin.
引用
收藏
页码：440 / 444
页数：4
相关论文
共 50 条
  • [41] Histone methyltransferase Suv39h1 represses MyoD-stimulated myogenic differentiation
    Mal, Asoke K.
    EMBO JOURNAL, 2006, 25 (14): : 3323 - 3334
  • [42] Histone methyltransferase SUV39H1 regulates the Golgi complex via the nuclear envelope-spanning LINC complex
    Nishino, Miyu
    Imaizumi, Hiromasa
    Yokoyama, Yuhki
    Katahira, Jun
    Kimura, Hiroshi
    Matsuura, Nariaki
    Matsumura, Miki
    PLOS ONE, 2023, 18 (07):
  • [43] The histone H3K9 methyltransferase SUV39H links SIRT1 repression to myocardial infarction
    Yang, Guang
    Weng, Xinyu
    Zhao, Yuhao
    Zhang, Xinjian
    Hu, Yuanping
    Dai, Xin
    Liang, Peng
    Wang, Peng
    Ma, LeiLei
    Sun, Xiaolei
    Hou, Lei
    Xu, Huihui
    Fang, Mingming
    Li, Yuehua
    Jenuwein, Thomas
    Xu, Yong
    Sun, Aijun
    NATURE COMMUNICATIONS, 2017, 8
  • [44] The histone H3K9 methyltransferase SUV39H links SIRT1 repression to myocardial infarction
    Guang Yang
    Xinyu Weng
    Yuhao Zhao
    Xinjian Zhang
    Yuanping Hu
    Xin Dai
    Peng Liang
    Peng Wang
    LeiLei Ma
    Xiaolei Sun
    Lei Hou
    Huihui Xu
    Mingming Fang
    Yuehua Li
    Thomas Jenuwein
    Yong Xu
    Aijun Sun
    Nature Communications, 8
  • [45] Role of Histone Lysine Methyltransferases SUV39H1 and SETDB1 in Gliomagenesis: Modulation of Cell Proliferation, Migration, and Colony Formation
    Spyropoulou, Anastasia
    Gargalionis, Antonios
    Dalagiorgou, Georgia
    Adamopoulos, Christos
    Papavassiliou, Kostas A.
    Lea, Robert William
    Piperi, Christina
    Papavassiliou, Athanasios G.
    NEUROMOLECULAR MEDICINE, 2014, 16 (01) : 70 - 82
  • [46] Methylation of SUV39H1 by SET7/9 results in heterochromatin relaxation and genome instability
    Wang, Donglai
    Zhou, Jingyi
    Liu, Xiangyu
    Lu, Danyu
    Shen, Changchun
    Du, Yipeng
    Wei, Fu-Zheng
    Song, Boyan
    Lu, Xiaopeng
    Yu, Yu
    Wang, Lina
    Zhao, Ying
    Wang, Haiying
    Yang, Yang
    Akiyama, Yoshimitsu
    Zhang, Hongquan
    Zhu, Wei-Guo
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2013, 110 (14) : 5516 - 5521
  • [47] Role of Histone Lysine Methyltransferases SUV39H1 and SETDB1 in Gliomagenesis: Modulation of Cell Proliferation, Migration, and Colony Formation
    Anastasia Spyropoulou
    Antonios Gargalionis
    Georgia Dalagiorgou
    Christos Adamopoulos
    Kostas A. Papavassiliou
    Robert William Lea
    Christina Piperi
    Athanasios G. Papavassiliou
    NeuroMolecular Medicine, 2014, 16 : 70 - 82
  • [48] The Influence of Histone Methyltransferase SUV39h1 on Hepatitis B Virus-Related Hepatocarcinogenesis
    Tsushima, Ken
    Tsuge, Masataka
    Uchida, Takuro
    Imamura, Michio
    Osawa, Mitutaka
    Teraoka, Yuji
    Abe-Chayama, Hiromi
    Makokha, Grace Naswa
    Aikata, Hiroshi
    Chayama, Kazuaki
    HEPATOLOGY, 2018, 68 : 328A - 329A
  • [49] Inhibition of SUV39H1 Methyltransferase Activity by DBC1
    Li, Zhenyu
    Chen, Lihong
    Kabra, Neha
    Wang, Chuangui
    Fang, Jia
    Chen, Jiandong
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2009, 284 (16) : 10361 - 10366
  • [50] Histone lysine methyltransferase SUV39H1 is a potent target for epigenetic therapy of hepatocellular carcinoma
    Chiba, Tetsuhiro
    Saito, Tomoko
    Yuki, Kaori
    Zen, Yoh
    Koide, Shuhei
    Kanogawa, Naoya
    Motoyama, Tenyu
    Ogasawara, Sadahisa
    Suzuki, Eiichiro
    Ooka, Yoshihiko
    Tawada, Akinobu
    Otsuka, Masayuki
    Miyazaki, Masaru
    Iwama, Atsushi
    Yokosuka, Osamu
    INTERNATIONAL JOURNAL OF CANCER, 2015, 136 (02) : 289 - 298
12345