SIRT1 regulates the histone methyl-transferase SUV39H1 during heterochromatin formation

被引：0
|
作者：
Alejandro Vaquero
Michael Scher
Hediye Erdjument-Bromage
Paul Tempst
Lourdes Serrano
Danny Reinberg
机构：
[1] Howard Hughes Medical Institute,Division of Nucleic Acids Enzymology, Department of Biochemistry
[2] University of Medicine and Dentistry of New Jersey,Department of Genetics
[3] Robert Wood Johnson Medical School,Department of Biochemistry
[4] Human Genetics Institute,undefined
[5] Rutgers University,undefined
[6] 145 Bevier Road,undefined
[7] Piscataway,undefined
[8] New Jersey 08854,undefined
[9] USA,undefined
[10] NYU-Medical School,undefined
[11] 522 First Avenue,undefined
[12] New York,undefined
[13] New York 10016,undefined
[14] USA,undefined
[15] Molecular Biology Program,undefined
[16] Memorial Sloan Kettering Cancer Center,undefined
[17] 1275 York Avenue,undefined
[18] New York,undefined
[19] New York 10021,undefined
[20] USA ,undefined
[21] Present address: ICREA and IBMB-CSIC/IRB,undefined
[22] Parc Cientific de Barcelona,undefined
[23] Josep Samitier 1–5,undefined
[24] 08028 Barcelona,undefined
[25] Spain.,undefined
来源：
Nature | 2007年 / 450卷
关键词：
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学科分类号：
摘要：
SUV39H1 is the major methyltransferase responsible for tri-methylation of histone H3 at lysine 9 in heterochromatin. The histone deacetylase SIRT1 is shown to target the SUV39H1 enzyme and contribute to elevated levels of SUV39H1 activity and H3K9me3 in heterochromatin.
引用
收藏
页码：440 / 444
页数：4
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