SIRT1 regulates the histone methyl-transferase SUV39H1 during heterochromatin formation

被引：0

作者：

Alejandro Vaquero

Michael Scher

Hediye Erdjument-Bromage

Paul Tempst

Lourdes Serrano

Danny Reinberg

机构：

[1] Howard Hughes Medical Institute,Division of Nucleic Acids Enzymology, Department of Biochemistry

[2] University of Medicine and Dentistry of New Jersey,Department of Genetics

[3] Robert Wood Johnson Medical School,Department of Biochemistry

[4] Human Genetics Institute,undefined

[5] Rutgers University,undefined

[6] 145 Bevier Road,undefined

[7] Piscataway,undefined

[8] New Jersey 08854,undefined

[9] USA,undefined

[10] NYU-Medical School,undefined

[11] 522 First Avenue,undefined

[12] New York,undefined

[13] New York 10016,undefined

[14] USA,undefined

[15] Molecular Biology Program,undefined

[16] Memorial Sloan Kettering Cancer Center,undefined

[17] 1275 York Avenue,undefined

[18] New York,undefined

[19] New York 10021,undefined

[20] USA ,undefined

[21] Present address: ICREA and IBMB-CSIC/IRB,undefined

[22] Parc Cientific de Barcelona,undefined

[23] Josep Samitier 1–5,undefined

[24] 08028 Barcelona,undefined

[25] Spain.,undefined

来源：

Nature | 2007年 / 450卷

关键词：

D O I：

暂无

中图分类号：

学科分类号：

摘要：

SUV39H1 is the major methyltransferase responsible for tri-methylation of histone H3 at lysine 9 in heterochromatin. The histone deacetylase SIRT1 is shown to target the SUV39H1 enzyme and contribute to elevated levels of SUV39H1 activity and H3K9me3 in heterochromatin.

引用

页码：440 / 444

页数：4

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