Local and Systemic Immune Responses to Intratracheal Instillation of Antigen and DNA Vaccines in Mice

被引：0
|
作者：
Catherine Lombry
Aline Marteleur
Mohammed Arras
Dominique Lison
Jamila Louahed
Jean-Christophe Renauld
Véronique Préat
Rita Vanbever
机构：
[1] Université catholique de Louvain (UCL),Department of Pharmaceutical Technology, School of Pharmacy
[2] School of Medicine,Industrial Toxicology and Occupational Medicine Unit
[3] UCL,undefined
[4] Ludwig Institute for Cancer Research and Experimental Medicine Unit,undefined
[5] UCL,undefined
来源：
Pharmaceutical Research | 2004年 / 21卷
关键词：
antigens and DNA vaccines; fate of vaccine molecule; IgG; intratracheal instillation; lungs; proliferation assay;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Purpose. The purpose of this study was to determine the immunization efficacy of antigen and DNA vaccines after delivery to the lung, to assess the integrity of the pulmonary tissue after vaccination, and to elucidate mechanisms involved in the induction of immunity.
引用
收藏
页码：127 / 135
页数：8
相关论文
共 50 条
  • [41] DNA vaccines: developing new strategies to enhance immune responses
    Abdulhaqq, Shaheed A.
    Weiner, David B.
    IMMUNOLOGIC RESEARCH, 2008, 42 (1-3) : 219 - 232
  • [42] Avian macrophages: Regulators of local and systemic immune responses
    Klasing, KC
    POULTRY SCIENCE, 1998, 77 (07) : 983 - 989
  • [43] Intestinal microbiota: Shaping local and systemic immune responses
    Molloy, Michael J.
    Bouladoux, Nicolas
    Belkaid, Yasmine
    SEMINARS IN IMMUNOLOGY, 2012, 24 (01) : 58 - 66
  • [44] DNA vaccines: developing new strategies to enhance immune responses
    Shaheed A. Abdulhaqq
    David B. Weiner
    Immunologic Research, 2008, 42 : 219 - 232
  • [45] Pulmonary toxicity of simulated lunar and Martian dusts in mice: II. Biomarkers of acute responses after intratracheal instillation
    Lam, CW
    James, JT
    Latch, JN
    Hamilton, RF
    Holian, A
    INHALATION TOXICOLOGY, 2002, 14 (09) : 917 - 928
  • [46] Inflammatory responses in mice after intratracheal instillation of spores of Streptomyces californicus isolated from indoor air of a moldy building
    Jussila, J
    Komulainen, H
    Huttunen, K
    Roponen, M
    Hälinen, A
    Hyvärinen, A
    Kosma, VM
    Pelkonen, J
    Hirvonen, MR
    TOXICOLOGY AND APPLIED PHARMACOLOGY, 2001, 171 (01) : 61 - 69
  • [47] LOCAL AND SYSTEMIC CELLULAR AND HUMORAL RESPONSES TO INHALED ANTIGEN IN THE RABBIT
    RICHERSON, HB
    BUTLER, JE
    RATAJCZAK, H
    SWANSON, P
    RICHARDS, DW
    JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 1979, 63 (03) : 205 - 205
  • [48] Characterization of immune responses induced by inactivated, live attenuated and DNA vaccines against Japanese encephalitis virus in mice
    Li, Jieqiong
    Chen, Hui
    Wu, Na
    Fan, Dongying
    Liang, Guodong
    Gao, Na
    An, Jing
    VACCINE, 2013, 31 (38) : 4136 - 4142
  • [49] Exploring local immune responses to vaccines using efferent lymphatic cannulation
    Mahakapuge, Thilini A. N.
    Every, Alison L.
    Scheerlinck, Jean-Pierre Y.
    EXPERT REVIEW OF VACCINES, 2015, 14 (04) : 579 - 588
  • [50] Intratracheal instillation of coal and coal fly ash particles in mice induces DNA damage and translocation of metals to extrapulmonary tissues
    Leon-Mejia, Grethel
    Machado, Mariana Nascimento
    Okuro, Renata Tiemi
    Silva, Luis F. O.
    Telles, Claudia
    Dias, Johnny
    Niekraszewicz, Liana
    Da Silva, Juliana
    Pegas Henriques, Joao Antonio
    Zin, Walter Araujo
    SCIENCE OF THE TOTAL ENVIRONMENT, 2018, 625 : 589 - 599
12345