Local and Systemic Immune Responses to Intratracheal Instillation of Antigen and DNA Vaccines in Mice

被引：0
|
作者：
Catherine Lombry
Aline Marteleur
Mohammed Arras
Dominique Lison
Jamila Louahed
Jean-Christophe Renauld
Véronique Préat
Rita Vanbever
机构：
[1] Université catholique de Louvain (UCL),Department of Pharmaceutical Technology, School of Pharmacy
[2] School of Medicine,Industrial Toxicology and Occupational Medicine Unit
[3] UCL,undefined
[4] Ludwig Institute for Cancer Research and Experimental Medicine Unit,undefined
[5] UCL,undefined
来源：
Pharmaceutical Research | 2004年 / 21卷
关键词：
antigens and DNA vaccines; fate of vaccine molecule; IgG; intratracheal instillation; lungs; proliferation assay;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Purpose. The purpose of this study was to determine the immunization efficacy of antigen and DNA vaccines after delivery to the lung, to assess the integrity of the pulmonary tissue after vaccination, and to elucidate mechanisms involved in the induction of immunity.
引用
收藏
页码：127 / 135
页数：8
相关论文
共 50 条
  • [31] ENTERICALLY INDUCED REGULATION OF SYSTEMIC IMMUNE-RESPONSES .1. LYMPHOPROLIFERATIVE RESPONSES IN MICE SUPPRESSED BY INGESTED ANTIGEN
    SILVERMAN, GA
    PERI, BA
    FITCH, FW
    ROTHBERG, RM
    JOURNAL OF IMMUNOLOGY, 1983, 131 (06): : 2651 - 2655
  • [32] Quantification of systemic and local immune responses to individual rotavirus proteins during rotavirus infection in mice
    Ishida, S
    Feng, NG
    Tang, BZ
    Gilbert, JM
    Greenberg, HB
    JOURNAL OF CLINICAL MICROBIOLOGY, 1996, 34 (07) : 1694 - 1700
  • [33] Effects of epitopes combination and adjuvants on immune responses to anti-Alzheimer disease DNA vaccines in mice
    He, Y
    Sun, SH
    Chen, RW
    Guo, YJ
    He, XW
    Huang, L
    Chen, ZH
    Shi, K
    Zhu, WJ
    ALZHEIMER DISEASE & ASSOCIATED DISORDERS, 2005, 19 (04): : 171 - 177
  • [34] Dendritic cell-targeting DNA vaccines elicited distinct immune responses directs by intracellular antigen trafficking
    Lee, B. K.
    Chen, Z. W.
    EUROPEAN JOURNAL OF IMMUNOLOGY, 2016, 46 : 1219 - 1219
  • [35] Local and systemic immune responses to Toxoplasma gondii in mice vaccinated intratracheally with live or attenuated tachyzoites
    Sayles, PC
    Gibson, GW
    Johnson, LL
    FASEB JOURNAL, 2002, 16 (05): : A1069 - A1069
  • [36] Bladder instillation of DNA-polyphosphoester nanospheres: transport, transfection, and immune responses
    Haller, Michael
    Malavaud, Bernard
    Le Visage, Catherine
    Leong, Kam
    2000, Am Inst Phys, Woodbury, NY, United States (28)
  • [37] Cutting edge: CpG DNA is a potent enhancer of systemic and mucosal immune responses against hepatitis B surface antigen with intranasal administration to mice
    McCluskie, MJ
    Davis, HL
    JOURNAL OF IMMUNOLOGY, 1998, 161 (09): : 4463 - 4466
  • [38] Immunostimulatory DNA-based vaccines elicit multifaceted immune responses against HIV at systemic and mucosal sites
    Horner, AA
    Datta, SK
    Takabayashi, K
    Belyakov, IM
    Hayashi, T
    Cinman, N
    Nguyen, MD
    Van Uden, JH
    Berzofsky, JA
    Richman, DD
    Raz, E
    JOURNAL OF IMMUNOLOGY, 2001, 167 (03): : 1584 - 1591
  • [39] Modulation of systemic antigen-specific immune responses by oral antigen in humans
    Kapp, Kerstin
    Maul, Jochen
    Hostmann, Arwed
    Mundt, Pamela
    Preiss, Jan C.
    Wenzel, Arlett
    Thiel, Andreas
    Zeitz, Martin
    Ullrich, Reiner
    Duchmann, Rainer
    EUROPEAN JOURNAL OF IMMUNOLOGY, 2010, 40 (11) : 3128 - 3137
  • [40] Modulation of immune responses to DNA vaccines by codelivery of cytokine genes
    Pan, CH
    Chen, HW
    Tao, MH
    JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION, 1999, 98 (11) : 722 - 729
12345