Current perspectives on Gleason grading of prostate cancer

被引：25
|
作者：
Iczkowski K.A. [1 ]
Lucia M.S. [1 ]
机构：
[1] Department of Pathology, University of Colorado Denver School of Medicine, Campus Mail Stop 8104, Aurora, CO 80045, RC-1 North
来源：
Current Urology Reports | 2011年 / 12卷 / 3期
关键词：
Grading; Modified Gleason; Pattern; Prostate cancer;
D O I：
10.1007/s11934-011-0181-5
中图分类号：
学科分类号：
摘要：
The 5-tier Gleason grading system for prostate cancer, introduced in 1966, has been proven to be one of the main independent predictors of prostate cancer outcome. This review addresses interobserver concordance in Gleason grading; the persistence of grading discrepancies with frequent upgrading from the biopsy to the prostatectomy specimen; the 2005 International Society of Urologic Pathologists' modifications to Gleason grading; the impact of this modified grading on grade migration and outcome prediction; and molecular correlates of cancer morphology. Data from the most recent years are emphasized. © 2011 Springer Science+Business Media, LLC.
引用
收藏
页码：216 / 222
页数：6
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