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S1P1 signaling just keeps going and going and going...
被引:0
|作者:
Stuart Cahalan
Hugh Rosen
机构:
[1] The Scripps Research Institute,Stuart Cahalan and Hugh Rosen are in the Departments of Chemical Physiology and Immunology
[2] ,undefined
[3] La Jolla California,undefined
[4] USA. hrosen@scripps.edu,undefined
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摘要:
Synthetic agonists of sphingosine-1-phosphate receptor subtype 1 are able to generate long-term signaling that persists for hours after ligand-induced receptor internalization. These signals are independent of agonist potency, can be reversed after receptor internalization by specific antagonists, and show a distinct acyl-chain-length structure-activity relationship.
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页码:377 / 378
页数:1
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