S1P1 signaling just keeps going and going and going...

被引：0

作者：

Stuart Cahalan

Hugh Rosen

机构：

[1] The Scripps Research Institute,Stuart Cahalan and Hugh Rosen are in the Departments of Chemical Physiology and Immunology

[2] ,undefined

[3] La Jolla California,undefined

[4] USA. hrosen@scripps.edu,undefined

来源：

Nature Chemical Biology | 2009年 / 5卷

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D O I：

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学科分类号：

摘要：

Synthetic agonists of sphingosine-1-phosphate receptor subtype 1 are able to generate long-term signaling that persists for hours after ligand-induced receptor internalization. These signals are independent of agonist potency, can be reversed after receptor internalization by specific antagonists, and show a distinct acyl-chain-length structure-activity relationship.

引用

页码：377 / 378

页数：1

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