Mechanisms of Disease: apoptosis in heart failure—seeing hope in death

被引：0
|
作者：
Jagat Narula
Nezam Haider
Eloisa Arbustini
Y Chandrashekhar
机构：
[1] the Professor of Medicine,
[2] Chief of the Division of Cardiology,undefined
[3] Associate Dean for Research at the University of California,undefined
[4] research scientist and directs the molecular cardiology laboratory at the University of California School of Medicine,undefined
[5] Professor of Pathology at the Policlinico San Matteo,undefined
[6] University of Minnesota School of Medicine,undefined
[7] VA Medical Center,undefined
来源：
Nature Clinical Practice Cardiovascular Medicine | 2006年 / 3卷
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摘要：
The loss of cardiomyocytes in failing or cardiomyopathic hearts is gradual and not accompanied by inflammation or major histomorphologic deformity. Apoptosis, therefore, seems to be the most logical mechanism of cell death. In this Review, Narula et al. discuss the role of apoptosis in systolic dysfunction and heart failure, and in the development of novel strategies for the management of heart failure.
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页码：681 / 688
页数：7
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