Glutathione peroxidase activity is neuroprotective in models of Huntington's disease

被引：0
|
作者：
Robert P Mason
Massimiliano Casu
Nicola Butler
Carlo Breda
Susanna Campesan
Jannine Clapp
Edward W Green
Devyani Dhulkhed
Charalambos P Kyriacou
Flaviano Giorgini
机构：
[1] University of Leicester,Department of Genetics
来源：
Nature Genetics | 2013年 / 45卷
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学科分类号：
摘要：
Flaviano Giorgini and colleagues perform an overexpression screen in yeast to identify genes that can suppress the toxic effects of the mutant Huntington's disease protein Htt. They identify glutathione peroxidase activity as a robust suppressor of mutant Htt toxicity and validate these protective effects in Drosophila and in mammalian cell models.
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页码：1249 / 1254
页数：5
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