Glutathione peroxidase activity is neuroprotective in models of Huntington's disease

被引：0

作者：

Robert P Mason

Massimiliano Casu

Nicola Butler

Carlo Breda

Susanna Campesan

Jannine Clapp

Edward W Green

Devyani Dhulkhed

Charalambos P Kyriacou

Flaviano Giorgini

机构：

[1] University of Leicester,Department of Genetics

来源：

Nature Genetics | 2013年 / 45卷

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D O I：

暂无

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学科分类号：

摘要：

Flaviano Giorgini and colleagues perform an overexpression screen in yeast to identify genes that can suppress the toxic effects of the mutant Huntington's disease protein Htt. They identify glutathione peroxidase activity as a robust suppressor of mutant Htt toxicity and validate these protective effects in Drosophila and in mammalian cell models.

引用

页码：1249 / 1254

页数：5

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