Comparison of Cinnarizine/Dimenhydrinate Fixed Combination with the Respective Monotherapies for Vertigo of Various OriginsA Randomized, Double-Blind, Active-Controlled, Multicentre Study

被引:0
|
作者
Ales Hahn
Miroslav Novotný
Penko M. Shotekov
Zdenek Cirek
Irene Bognar-Steinberg
Wolfgang Baumann
机构
[1] Charles University Prague,ENT Department
[2] Third Medical Faculty and Faculty Hospital Královské Vinohrady,ENT Clinic
[3] Masaryk University,First Neurological Clinic
[4] Medical Academy,ENT Clinic
[5] Charles University,Department of Clinical Research
[6] Hennig Arzneimittel,undefined
来源
关键词
Fixed Combination; Benign Paroxysmal Positional Vertigo; Cinnarizine; Dimenhydrinate; Vestibular Disorder;
D O I
暂无
中图分类号
学科分类号
摘要
Background and Objective: Vertigo may arise from dysfunction in the peripheral and/or the central vestibular system. Simultaneous activity of a medication at both sites will serve to improve the efficacy of antivertigo treatment. The aim of this study was to compare the efficacy and tolerability of a fixed combination of the peripherally acting cinnarizine (20 mg) plus the centrally acting dimenhydrinate (40 mg) with those of equally dosed monotherapies in the treatment of vertigo of various origins.
引用
收藏
页码:371 / 383
页数:12
相关论文
共 50 条
  • [21] A Randomized, Double-blind, Active-Controlled, Multi-center Study of Ilaprazole in the Treatment of Reflux Esophagitis
    Xue, Yan
    Qin, Xianghong
    Zhou, Liya
    Lin, Sanren
    Wang, Ling
    Hu, Haitang
    Xia, Jielai
    CLINICAL DRUG INVESTIGATION, 2016, 36 (12) : 985 - 992
  • [22] Ilaprazole Compared With Rabeprazole in the Treatment of Duodenal Ulcer A Randomized, Double-blind, Active-controlled, Multicenter Study
    Li Fan
    Qin Xianghong
    Wang Ling
    Han Ying
    Xia Jielai
    Hu Haitang
    JOURNAL OF CLINICAL GASTROENTEROLOGY, 2019, 53 (09) : 641 - 647
  • [23] A Randomized, Double-blind, Active-Controlled, Multi-center Study of Ilaprazole in the Treatment of Reflux Esophagitis
    Yan Xue
    Xianghong Qin
    Liya Zhou
    Sanren Lin
    Ling Wang
    Haitang Hu
    Jielai Xia
    Clinical Drug Investigation, 2016, 36 : 985 - 992
  • [24] Comparison of topiroxostat and allopurinol in Japanese hyperuricemic patients with or without gout: a phase 3, multicentre, randomized, double-blind, double-dummy, active-controlled, parallel-group study
    Hosoya, T.
    Ogawa, Y.
    Hashimoto, H.
    Ohashi, T.
    Sakamoto, R.
    JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS, 2016, 41 (03) : 290 - 297
  • [25] A Double-Blind, Randomized, Placebo and Active-Controlled Study of Nebicapone for the Treatment of Motor Fluctuations in Parkinson's Disease
    Ferreira, Joaquim J.
    Rascol, Olivier
    Poewe, Werner
    Sampaio, Cristina
    Rocha, Jose-Francisco
    Nunes, Teresa
    Almeida, Luis
    Soares-da-Silva, Patricio
    CNS NEUROSCIENCE & THERAPEUTICS, 2010, 16 (06) : 337 - 347
  • [26] Phase III randomized, double-blind, active-controlled study of momelotinib versus ruxolitinib in patients with myelofibrosis.
    Winton, Elliott F.
    Devos, Timothy
    Oh, Stephen T.
    Platzbecker, Uwe
    Wadleigh, Martha
    Jun, Susie
    Lee, Peter
    Deng, Wei
    Gupta, Vikas
    JOURNAL OF CLINICAL ONCOLOGY, 2015, 33 (15)
  • [27] Efficacy and Safety of a Fixed-Dose Combination of Cinnarizine 20 mg and Dimenhydrinate 40 mg in the Treatment of Patients with Vestibular Vertigo: An Individual Patient Data Meta-Analysis of Randomised, Double-Blind, Controlled Clinical Trials
    Arne W. Scholtz
    Frank Waldfahrer
    Regina Hampel
    Gerhard Weisshaar
    Clinical Drug Investigation, 2022, 42 : 705 - 720
  • [28] Efficacy and Safety of a Fixed-Dose Combination of Cinnarizine 20 mg and Dimenhydrinate 40 mg in the Treatment of Patients with Vestibular Vertigo: An Individual Patient Data Meta-Analysis of Randomised, Double-Blind, Controlled Clinical Trials
    Scholtz, Arne W.
    Waldfahrer, Frank
    Hampel, Regina
    Weisshaar, Gerhard
    CLINICAL DRUG INVESTIGATION, 2022, 42 (09) : 705 - 720
  • [29] Combination of retagliptin and henagliflozin as add-on therapy to metformin in patients with type 2 diabetes inadequately controlled with metformin: A multicentre, randomized, double-blind, active-controlled, phase 3 trial
    Wang, Yao
    Jiang, Chengxia
    Dong, Xiaolin
    Chen, Mingwei
    Gu, Qin
    Zhang, Lihui
    Fu, Yanqin
    Pan, Tianrong
    Bi, Yan
    Song, Weihong
    Xu, Jing
    Lu, Weiping
    Sun, Xiaodong
    Ye, Zi
    Zhang, Danli
    Peng, Liang
    Lin, Xiang
    Dai, Wei
    Wang, Quanren
    Yang, Wenying
    DIABETES OBESITY & METABOLISM, 2024, 26 (07): : 2774 - 2786
  • [30] Efficacy and safety of evogliptin treatment in patients with type 2 diabetes: A multicentre, active-controlled, randomized, double-blind study with open-label extension (the EVERGREEN study)
    Kim, Gyuri
    Lim, Soo
    Kwon, Hyuk-Sang
    Park, Ie B.
    Ahn, Kyu J.
    Park, Cheol-Young
    Kwon, Su K.
    Kim, Hye S.
    Park, Seok W.
    Kim, Sin G.
    Moon, Min K.
    Kim, Eun S.
    Chung, Choon H.
    Park, Kang S.
    Kim, Mikyung
    Chung, Dong J.
    Lee, Chang B.
    Kim, Tae H.
    Lee, Moon-Kyu
    DIABETES OBESITY & METABOLISM, 2020, 22 (09): : 1527 - 1536