A case of acute eosinophilic granulocytic leukemia with PML-RAR alpha fusion gene expression and response to all-trans retinoic acid

被引：0
|
作者：
R-Q Yu
W Huang
S-J Chen
S-D Jiang
Z Chen
机构：
[1] Shanghai Chang-Zheng Hospital,Division of Hematology, Department of Internal Medicine
[2] Laboratory of Molecular Biology,undefined
[3] Shanghai Institute of Hematology,undefined
来源：
Leukemia | 1997年 / 11卷
关键词：
leukemia; eosinophilic; PML-RAR alpha; retinoic acid;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
A typical case of eosinophilic granulocytic leukemia with PML-RAR alpha fusion gene expression is reported. The patient achieved complete remission after oral administration of all-trans retinoic acid without any exposure to cytotoxic agents. The facts strongly suggest that the genetic event occurred at the level of pluripotent stem cells.
引用
收藏
页码：609 / 611
页数：2
相关论文
共 50 条
  • [41] Interferon augments PML and PML/RAR alpha expression in normal myeloid and acute promyelocytic cells and cooperates with all-trans retinoic acid to induce maturation of a retinoid resistant promyelocytic cell line
    NasonBurchenal, K
    Gandini, D
    Botto, M
    Allopenna, J
    Seale, JRC
    Cross, NCP
    Goldman, JM
    Dmitrovsky, E
    Pandolfi, PP
    BLOOD, 1995, 86 (10) : 671 - 671
  • [42] Effects of all-trans retinoic acid on gene expression and proliferation of promyelocytic leukemia cells
    Nitto, Takeaki
    Takahashi, Mizuki
    Honta, Katsuya
    Tanaka, Kenta
    Nagashima, Daichi
    Sawaki, Kouhei
    JOURNAL OF PHARMACOLOGICAL SCIENCES, 2014, 124 : 202P - 202P
  • [43] Frequent mutations in the ligand-binding domain of PML-RARα after multiple relapses of acute promyeloicytic leukemia:: Analysis for functional relationship to response to all-trans retinoic acid and histone deacetylase inhibitors in vitro and in vivo
    Zhou, DC
    Kim, SH
    Ding, W
    Schultz, C
    Warrell, RP
    Gallagher, RE
    BLOOD, 2002, 99 (04) : 1356 - 1363
  • [44] A retrovirus carrying the promyelocyte-retinoic acid receptor PML-RAR alpha fusion gene transforms haematopoietic progenitors in vitro and induces acute leukaemias
    Altabef, M
    Garcia, M
    Lavau, C
    Bae, SC
    Dejean, A
    Samarut, J
    EMBO JOURNAL, 1996, 15 (11): : 2707 - 2716
  • [45] Removal of the dominant negative PML-RARα protein and upregulation of C/EBPε expression are necessary for all trans retinoic acid-induced differentiation of acute promyelocytic leukemia cells.
    Jing, YK
    Xia, LJ
    Waxman, S
    BLOOD, 2001, 98 (11) : 306A - 306A
  • [46] Arsenic trioxide cooperates with all-trans retinoic acid to enhance mitogen-activated protein kinase activation and differentiation in PML-RARα negative human myeloblastic leukemia cells
    Nayak, Satyaprakash
    Shen, Miaoqing
    Bunaciu, Rodica P.
    Bloom, Stephen E.
    Varner, Jeffrey D.
    Yen, Andrew
    LEUKEMIA & LYMPHOMA, 2010, 51 (09) : 1734 - 1747
  • [47] Interferon augments PML and PML/RAR alpha expression in normal myeloid and acute promyelocytic cells and cooperates with all-trans retinoic acid to induce maturation of a retinoid-resistant promyelocytic cell line
    NasonBurchenal, K
    Gandini, D
    Botto, M
    Allopenna, J
    Seale, JRC
    Cross, NCP
    Goldman, JM
    Dmitrovsky, E
    Pandolfi, PP
    BLOOD, 1996, 88 (10) : 3926 - 3936
  • [48] Differentiating therapy with all-trans retinoic acid in acute myeloid leukemia
    Tallman, MS
    LEUKEMIA, 1996, 10 : S12 - S15
  • [49] Therapy of acute promyelocytic leukemia:: All-trans retinoic acid and beyond
    Tallman, MS
    LEUKEMIA, 1998, 12 : S37 - S40
  • [50] All-trans retinoic acid and chemotherapy in the treatment of acute promyelocytic leukemia
    Fenaux, P
    Chomienne, C
    Degos, L
    SEMINARS IN HEMATOLOGY, 2001, 38 (01) : 13 - 25
12345