A case of acute eosinophilic granulocytic leukemia with PML-RAR alpha fusion gene expression and response to all-trans retinoic acid

被引:0
|
作者
R-Q Yu
W Huang
S-J Chen
S-D Jiang
Z Chen
机构
[1] Shanghai Chang-Zheng Hospital,Division of Hematology, Department of Internal Medicine
[2] Laboratory of Molecular Biology,undefined
[3] Shanghai Institute of Hematology,undefined
来源
Leukemia | 1997年 / 11卷
关键词
leukemia; eosinophilic; PML-RAR alpha; retinoic acid;
D O I
暂无
中图分类号
学科分类号
摘要
A typical case of eosinophilic granulocytic leukemia with PML-RAR alpha fusion gene expression is reported. The patient achieved complete remission after oral administration of all-trans retinoic acid without any exposure to cytotoxic agents. The facts strongly suggest that the genetic event occurred at the level of pluripotent stem cells.
引用
收藏
页码:609 / 611
页数:2
相关论文
共 50 条
  • [21] Distinct gene expression profiles underlying trichostatin A and all-trans-retinoic acid -: Induced growth inhibiton of PML-RARα and PLZF-RARα Acute Promyelocytic Leukemia cells.
    Teixeira, HLG
    Junta, CM
    Lima, ASG
    Campos, TMC
    Falcao, RP
    Passos, GA
    Rego, EM
    BLOOD, 2002, 100 (11) : 561A - 562A
  • [22] Mutations in the E-domain of RARα portion of the PML/RARα chimeric gene may confer clinical resistance to all-trans retinoic acid in acute promyelocytic leukemia
    Imaizumi, M
    Suzuki, H
    Yoshinari, M
    Sato, A
    Saito, T
    Sugawara, A
    Tsuchiya, S
    Hatae, Y
    Fujimoto, T
    Kakizuka, A
    Konno, T
    Iinuma, K
    BLOOD, 1998, 92 (02) : 374 - 382
  • [23] The cleavage product ΔPML–RARα contributes to all-trans retinoic acid-mediated differentiation in acute promyelocytic leukemia cells
    Yongkui Jing
    Lijuan Xia
    Min Lu
    Samuel Waxman
    Oncogene, 2003, 22 : 4083 - 4091
  • [24] In vitro response to all-trans retinoic acid of acute promyelocytic leukemias with nonreciprocal PML/RARA or RARA/PML fusion genes
    Mozziconacci, MJ
    Liberatore, C
    Brunel, V
    Grignani, F
    Arnoulet, C
    Ferrucci, PF
    Fernandez, F
    Sainty, D
    Pelicci, PG
    Birg, F
    Lafage-Pochitaloff, M
    GENES CHROMOSOMES & CANCER, 1998, 22 (03): : 241 - 250
  • [25] PML-RARα induces all-trans retinoic acid-dependent transcriptional activation through interaction with MED1
    Fukuoka, Tomoya
    Kawai, Asami
    Takahara, Taku
    Mori, Mahiro
    Roeder, Robert G.
    Hasegawa, Natsumi
    Ito, Mitsuhiro
    TRANSCRIPTION-AUSTIN, 2019, 10 (03): : 147 - 156
  • [26] Retroviral vectors for the transduction of the PML-RAR alpha fusion product of acute promyelocytic leukemia
    Lavau, C
    Heard, JM
    Danos, O
    Dejean, A
    EXPERIMENTAL HEMATOLOGY, 1996, 24 (04) : 544 - 551
  • [27] Influence of bcr-3 PML-RARα transcript on outcome in Acute Promyelocytic Leukemia patients of Kashmir treated with all-trans retinoic acid and/or arsenic tri-oxide
    Baba, Shahid M.
    Shah, Zafar A.
    Pandith, Arshad A.
    Dil-Afroze
    Jan, Aleem
    Mir, Khurshid A.
    Aziz, Sheikh A.
    Ahmad, Zahoor
    CANCER GENETICS, 2019, 231 : 14 - 21
  • [28] EXPRESSION PATTERN OF THE RAR-ALPHA-PML FUSION GENE IN ACUTE PROMYELOCYTIC LEUKEMIA
    ALCALAY, M
    ZANGRILLI, D
    FAGIOLI, M
    PANDOLFI, PP
    MENCARELLI, A
    LOCOCO, F
    BIONDI, A
    GRIGNANI, F
    PELICCI, PG
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (11) : 4840 - 4844
  • [29] All-trans retinoic acid (ATRA) treatment of acute promyelocytic leukemia NB4 cells results in cleavage of PML-RARα protein that is independent of proteosome and caspase pathways.
    Xia, LJ
    Min, L
    Waxman, S
    Jing, YK
    BLOOD, 2002, 100 (11) : 541A - 541A
  • [30] PML-RARα fusion gene transcripts and biological features in acute promyelocytic leukemia patients
    Melo, RAM
    De Vasconcellos, JF
    Melo, FCBC
    Machado, CGF
    Lacerda, TMS
    Souto, FR
    CLINICAL AND LABORATORY HAEMATOLOGY, 2006, 28 (02): : 126 - 129