Autophagy deficiency leads to protection from obesity and insulin resistance by inducing Fgf21 as a mitokine

被引：0

作者：

Kook Hwan Kim

Yeon Taek Jeong

Hyunhee Oh

Seong Hun Kim

Jae Min Cho

Yo-Na Kim

Su Sung Kim

Do Hoon Kim

Kyu Yeon Hur

Hyoung Kyu Kim

TaeHee Ko

Jin Han

Hong Lim Kim

Jin Kim

Sung Hoon Back

Masaaki Komatsu

Hsiuchen Chen

David C Chan

Morichika Konishi

Nobuyuki Itoh

Cheol Soo Choi

Myung-Shik Lee

机构：

[1] Samsung Medical Center,Department of Medicine

[2] Sungkyunkwan University School of Medicine,Department of Physiology

[3] Samsung Advanced Institute for Health Sciences and Technology,Department of Anatomy and Cell Death Disease Research Center

[4] Sungkyunkwan University School of Medicine,Division of Biology

[5] Korea Mouse Metabolic Phenotyping Center,Department of Microbial Chemistry

[6] Lee Gil Ya Cancer and Diabetes Institute,Department of Genetic Biochemistry

[7] Gachon University Graduate School of Medicine,Department of Internal Medicine

[8] National Research Laboratory for Mitochondrial Signaling,undefined

[9] College of Medicine,undefined

[10] Cardiovascular and Metabolic Disease Center,undefined

[11] FIRST Mitochondrial Research Group,undefined

[12] Inje University,undefined

[13] Integrative Research Support Center,undefined

[14] College of Medicine,undefined

[15] The Catholic University of Korea,undefined

[16] College of Medicine,undefined

[17] The Catholic University of Korea,undefined

[18] School of Biological Sciences,undefined

[19] University of Ulsan,undefined

[20] Protein Metabolism Project,undefined

[21] Tokyo Metropolitan Institute of Medical Science,undefined

[22] California Institute of Technology,undefined

[23] Howard Hughes Medical Institute,undefined

[24] California Institute of Technology,undefined

[25] Kobe Pharmaceutical University,undefined

[26] Kyoto University Graduate School of Pharmaceutical Sciences,undefined

[27] Gil Medical Center,undefined

[28] Gachon University Graduate School of Medicine,undefined

来源：

Nature Medicine | 2013年 / 19卷

关键词：

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Defects in mitochondrial function have been believed to contribute to insulin resistance. Myung-Shik Lee and colleagues now show that mitochondrial dysfunction in muscle induced by tissue-specific deficiency of autophagy results in upregulation of Fgf21 and improved metabolism, suggesting that at least some mitochondrial dysfunction may actually be beneficial.

引用

页码：83 / 92

页数：9

共 50 条

[21] Impaired Fibroblast Growth Factor 21 (FGF21) Associated with Visceral Adiposity Leads to Insulin Resistance: The Core Defect in Diabetes Mellitus
Jain, Unnati
Srivastava, Priyanka
Sharma, Ashwani
Sinha, Subrata
Johari, Surabhi
CURRENT DIABETES REVIEWS, 2025, 21 (05)
[22] Inhibition of insulin resistance by PGE1 via autophagy-dependent FGF21 pathway in diabetic nephropathy
Wei Wei
Xing-Rong An
Shi-Jie Jin
Xiao-Xue Li
Ming Xu
Scientific Reports, 8
[23] Inhibition of insulin resistance by PGE1 via autophagy-dependent FGF21 pathway in diabetic nephropathy
Wei, Wei
An, Xing-Rong
Jin, Shi-Jie
Li, Xiao-Xue
Xu, Ming
SCIENTIFIC REPORTS, 2018, 8
[24] Hepatic tristetraprolin promotes insulin resistance through RNA destabilization of FGF21
Sawicki, Konrad T.
Chang, Hsiang-Chun
Shapiro, Jason S.
Bayeva, Marina
De Jesus, Adam
Finck, Brian N.
Wertheim, Jason A.
Blackshear, Perry J.
Ardehali, Hossein
JCI INSIGHT, 2018, 3 (13)
[25] Adipose Modeling of FGF21 Signaling Mutations in a Severe Insulin Resistance Syndrome
Nhung Phan
Ornitz, David M.
Stone, Stephen I.
DIABETES, 2022, 71
[26] FGF21 alleviates acute liver injury by inducing the SIRT1-autophagy signalling pathway
Yang, Xiaoning
Jin, Zhongqian
Lin, Danfeng
Shen, Tianzhu
Zhang, Jiangnan
Li, Dan
Wang, Xuye
Zhang, Chi
Lin, Zhuofeng
Li, Xiaokun
Gong, Fanghua
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 2022, 26 (03) : 868 - 879
[27] FGF21 serum levels are related to insulin resistance, metabolic changes and obesity in Mexican people living with HIV (PLWH)
Ivonne Urraza-Robledo, Arguine
Giralt, Marta
Francisco Gonzalez-Galarza, Faviel
Villarroya, Francesc
Miranda Perez, Alberto Alejandro
Ruiz Flores, Pablo
Gutierrez Perez, Maria Elena
Domingo, Pere
Carlos Lopez-Marquez, Francisco
PLOS ONE, 2021, 16 (05):
[28] The Close Relationship between Insulin Resistance and FGF21 Resistance in Human Skeletal Muscle Models
Jeon, Ja Young
Lee, Min Suk
Ha, Eun Suk
Choi, Sung-E
Kim, Tae Ho
Ahn, So-Yeon
Han, Seung Jin
Kim, Hae Jin
Kim, Dae Jung
Kang, Yup
Lee, Kwan Woo
DIABETES, 2013, 62 : A517 - A517
[29] FGF21 resistance relevant to insulin resistance in skeletal muscle of patients with type 2 diabetes
Lee, M.
Jeon, J.
Ha, E.
Choi, S. -E.
Kim, T.
Ahn, S. -Y.
Han, S.
Kim, H.
Kim, D.
Kang, Y.
Lee, K. -W.
DIABETOLOGIA, 2013, 56 : S36 - S36
[30] Genetic and Diet Induced Obesity are Associated with FGF21 Resistance in Adipose Tissue and Liver
Fisher, Ffolliott Martin
Adams, Andrew
Antonellis, Patrick
Kharitonenkov, Alexei
Flier, Jeffrey
Maratos-Flier, Eleftheria
OBESITY, 2009, 17 : S68 - S68

← 1 2 3 4 5 →