Autophagy deficiency leads to protection from obesity and insulin resistance by inducing Fgf21 as a mitokine

被引：0

作者：

Kook Hwan Kim

Yeon Taek Jeong

Hyunhee Oh

Seong Hun Kim

Jae Min Cho

Yo-Na Kim

Su Sung Kim

Do Hoon Kim

Kyu Yeon Hur

Hyoung Kyu Kim

TaeHee Ko

Jin Han

Hong Lim Kim

Jin Kim

Sung Hoon Back

Masaaki Komatsu

Hsiuchen Chen

David C Chan

Morichika Konishi

Nobuyuki Itoh

Cheol Soo Choi

Myung-Shik Lee

机构：

[1] Samsung Medical Center,Department of Medicine

[2] Sungkyunkwan University School of Medicine,Department of Physiology

[3] Samsung Advanced Institute for Health Sciences and Technology,Department of Anatomy and Cell Death Disease Research Center

[4] Sungkyunkwan University School of Medicine,Division of Biology

[5] Korea Mouse Metabolic Phenotyping Center,Department of Microbial Chemistry

[6] Lee Gil Ya Cancer and Diabetes Institute,Department of Genetic Biochemistry

[7] Gachon University Graduate School of Medicine,Department of Internal Medicine

[8] National Research Laboratory for Mitochondrial Signaling,undefined

[9] College of Medicine,undefined

[10] Cardiovascular and Metabolic Disease Center,undefined

[11] FIRST Mitochondrial Research Group,undefined

[12] Inje University,undefined

[13] Integrative Research Support Center,undefined

[14] College of Medicine,undefined

[15] The Catholic University of Korea,undefined

[16] College of Medicine,undefined

[17] The Catholic University of Korea,undefined

[18] School of Biological Sciences,undefined

[19] University of Ulsan,undefined

[20] Protein Metabolism Project,undefined

[21] Tokyo Metropolitan Institute of Medical Science,undefined

[22] California Institute of Technology,undefined

[23] Howard Hughes Medical Institute,undefined

[24] California Institute of Technology,undefined

[25] Kobe Pharmaceutical University,undefined

[26] Kyoto University Graduate School of Pharmaceutical Sciences,undefined

[27] Gil Medical Center,undefined

[28] Gachon University Graduate School of Medicine,undefined

来源：

Nature Medicine | 2013年 / 19卷

关键词：

D O I：

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中图分类号：

学科分类号：

摘要：

Defects in mitochondrial function have been believed to contribute to insulin resistance. Myung-Shik Lee and colleagues now show that mitochondrial dysfunction in muscle induced by tissue-specific deficiency of autophagy results in upregulation of Fgf21 and improved metabolism, suggesting that at least some mitochondrial dysfunction may actually be beneficial.

引用

页码：83 / 92

页数：9

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