Autophagy deficiency leads to protection from obesity and insulin resistance by inducing Fgf21 as a mitokine

被引：0

作者：

Kook Hwan Kim

Yeon Taek Jeong

Hyunhee Oh

Seong Hun Kim

Jae Min Cho

Yo-Na Kim

Su Sung Kim

Do Hoon Kim

Kyu Yeon Hur

Hyoung Kyu Kim

TaeHee Ko

Jin Han

Hong Lim Kim

Jin Kim

Sung Hoon Back

Masaaki Komatsu

Hsiuchen Chen

David C Chan

Morichika Konishi

Nobuyuki Itoh

Cheol Soo Choi

Myung-Shik Lee

机构：

[1] Samsung Medical Center,Department of Medicine

[2] Sungkyunkwan University School of Medicine,Department of Physiology

[3] Samsung Advanced Institute for Health Sciences and Technology,Department of Anatomy and Cell Death Disease Research Center

[4] Sungkyunkwan University School of Medicine,Division of Biology

[5] Korea Mouse Metabolic Phenotyping Center,Department of Microbial Chemistry

[6] Lee Gil Ya Cancer and Diabetes Institute,Department of Genetic Biochemistry

[7] Gachon University Graduate School of Medicine,Department of Internal Medicine

[8] National Research Laboratory for Mitochondrial Signaling,undefined

[9] College of Medicine,undefined

[10] Cardiovascular and Metabolic Disease Center,undefined

[11] FIRST Mitochondrial Research Group,undefined

[12] Inje University,undefined

[13] Integrative Research Support Center,undefined

[14] College of Medicine,undefined

[15] The Catholic University of Korea,undefined

[16] College of Medicine,undefined

[17] The Catholic University of Korea,undefined

[18] School of Biological Sciences,undefined

[19] University of Ulsan,undefined

[20] Protein Metabolism Project,undefined

[21] Tokyo Metropolitan Institute of Medical Science,undefined

[22] California Institute of Technology,undefined

[23] Howard Hughes Medical Institute,undefined

[24] California Institute of Technology,undefined

[25] Kobe Pharmaceutical University,undefined

[26] Kyoto University Graduate School of Pharmaceutical Sciences,undefined

[27] Gil Medical Center,undefined

[28] Gachon University Graduate School of Medicine,undefined

来源：

Nature Medicine | 2013年 / 19卷

关键词：

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Defects in mitochondrial function have been believed to contribute to insulin resistance. Myung-Shik Lee and colleagues now show that mitochondrial dysfunction in muscle induced by tissue-specific deficiency of autophagy results in upregulation of Fgf21 and improved metabolism, suggesting that at least some mitochondrial dysfunction may actually be beneficial.

引用

页码：83 / 92

页数：9

共 50 条

[1] Autophagy deficiency leads to protection from obesity and insulin resistance by inducing Fgf21 as a mitokine
Kim, Kook Hwan
Jeong, Yeon Taek
Oh, Hyunhee
Kim, Seong Hun
Cho, Jae Min
Kim, Yo-Na
Kim, Su Sung
Kim, Do Hoon
Hur, Kyu Yeon
Kim, Hyoung Kyu
Ko, TaeHee
Han, Jin
Kim, Hong Lim
Kim, Jin
Back, Sung Hoon
Komatsu, Masaaki
Chen, Hsiuchen
Chan, David C.
Konishi, Morichika
Itoh, Nobuyuki
Choi, Cheol Soo
Lee, Myung-Shik
NATURE MEDICINE, 2013, 19 (01) : 83 - 92
[2] FGF21 deficiency is associated with childhood obesity, insulin resistance and hypoadiponectinaemia: The BCAMS Study
Li, G.
Yin, J.
Fu, J.
Li, L.
Grant, S. F. A.
Li, C.
Li, M.
Mi, J.
Li, M.
Gao, S.
DIABETES & METABOLISM, 2017, 43 (03) : 253 - 260
[3] FGF21 gene therapy as treatment for obesity and insulin resistance
Jimenez, Veronica
Jambrina, Claudia
Casana, Estefania
Sacristan, Victor
Munoz, Sergio
Darriba, Sara
Rodo, Jordi
Mallol, Cristina
Garcia, Miquel
Leon, Xavier
Marco, Sara
Ribera, Albert
Elias, Ivet
Casellas, Alba
Grass, Ignasi
Elias, Gemma
Ferre, Tura
Motas, Sandra
Franckhauser, Sylvie
Mulero, Francisca
Navarro, Marc
Haurigot, Virginia
Ruberte, Jesus
Bosch, Fatima
EMBO MOLECULAR MEDICINE, 2018, 10 (08)
[4] OPA1 deficiency promotes secretion of FGF21 from muscle that prevents obesity and insulin resistance
Pereira, Renata Oliveira
Tadinada, Satya M.
Zasadny, Frederick M.
Oliveira, Karen Jesus
Pires, Karla Maria Pereira
Olvera, Angela
Jeffers, Jennifer
Souvenir, Rhonda
Mcglauflin, Rose
Seei, Alec
Funari, Trevor
Sesaki, Hiromi
Potthoff, Matthew J.
Adams, Christopher M.
Anderson, Ethan J.
Abel, E. Dale
EMBO JOURNAL, 2017, 36 (14): : 2126 - 2145
[5] Lack of Overt FGF21 Resistance in Two Mouse Models of Obesity and Insulin Resistance
Hale, Clarence
Chen, Michelle M.
Stanislaus, Shanaka
Chinookoswong, Narumol
Hager, Todd
Wang, Minghan
Veniant, Murielle M.
Xu, Jing
ENDOCRINOLOGY, 2012, 153 (01) : 69 - 80
[6] Editorial: FGF21 as a therapeutic target for obesity and insulin resistance: from rodent models to humans
De Sousa-Coelho, A. L.
Rodriguez-Rodriguez, R.
Softic, S.
Jonker, J. W.
Relat, J.
FRONTIERS IN ENDOCRINOLOGY, 2023, 14
[7] Liver directed FGF21 gene therapy reverses obesity and insulin resistance
Jambrina, C.
Jimenez, V.
Casana, E.
Sacristan, V.
Munoz, S.
Darriba, S.
Rodo, J.
Garcia, M.
Marco, S.
Ribera, A.
Elias, I.
Casellas, A.
Grass, I.
Ruberte, J.
Bosch, F.
DIABETOLOGIA, 2018, 61 : S325 - S325
[8] FGF21 ameliorates nonalcoholic fatty liver disease by inducing autophagy
Shenglong Zhu
Yunzhou Wu
Xianlong Ye
Lei Ma
Jianying Qi
Dan Yu
Yuquan Wei
Guangxiao Lin
Guiping Ren
Deshan Li
Molecular and Cellular Biochemistry, 2016, 420 : 107 - 119
[9] FGF21 ameliorates nonalcoholic fatty liver disease by inducing autophagy
Zhu, Shenglong
Wu, Yunzhou
Ye, Xianlong
Ma, Lei
Qi, Jianying
Yu, Dan
Wei, Yuquan
Lin, Guangxiao
Ren, Guiping
Li, Deshan
MOLECULAR AND CELLULAR BIOCHEMISTRY, 2016, 420 (1-2) : 107 - 119
[10] Defective autophagy causes a maladaptive cardiac phenotype to exercise that leads to premature death and FGF21-mediated protection against obesity and insulin resistance
Lira, Vitor A.
Kronemberge, Ana
Call, Jarrod A.
Caster, Hannah M.
Pereira, Renata O.
Laker, Rhianna C.
Zhang, Mei
Yan, Zhen
FASEB JOURNAL, 2016, 30

← 1 2 3 4 5 →