Inhibition of β-catenin and STAT3 with a curcumin analog suppresses gastric carcinogenesis in vivo

被引：0
|
作者：
Yoshihiko Uehara
Masahiro Inoue
Koji Fukuda
Hiroyuki Yamakoshi
Yoshio Hosoi
Hiroaki Kanda
Masanobu Oshima
Yoshiharu Iwabuchi
Hiroyuki Shibata
机构：
[1] Tohoku University,Department of Cell Biology, Graduate School of Medicine
[2] Akita University,Department of Clinical Oncology, Graduate School of Medicine
[3] Tohoku University,Department of Organic Chemistry, Graduate School of Pharmaceutical Science
[4] Japanese Foundation for Cancer Research,Division of Pathology, Cancer Institute
[5] Kanazawa University,Division of Genetics, Cancer Research Institute
来源：
Gastric Cancer | 2015年 / 18卷
关键词：
Analog; β-Catenin; Curcumin; Gastric cancer; Signal transducer and activator of transcription 3;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
引用
收藏
页码：774 / 783
页数：9
相关论文
共 50 条
  • [31] Targeting STAT3 in gastric cancer
    Giraud, Andrew S.
    Menheniott, Trevelyan R.
    Judd, Louise M.
    EXPERT OPINION ON THERAPEUTIC TARGETS, 2012, 16 (09) : 889 - 901
  • [32] HO-3867, a curcumin analog, sensitizes cisplatin-resistant ovarian carcinoma, leading to therapeutic synergy through STAT3 inhibition
    Selvendiran, Karuppaiyah
    Ahmed, Shabnam
    Dayton, Alex
    Kuppusamy, M. Lakshmi
    Rivera, Brian K.
    Kalai, Tamas
    Hideg, Kalman
    Kuppusamy, Periannan
    CANCER BIOLOGY & THERAPY, 2011, 12 (09) : 837 - 845
  • [33] The small molecule curcumin analog FLLL-32 induces apoptosis in human melanoma cells via STAT3 inhibition and elicits in vivo anti-tumor activity.
    Lesinski, Gregory
    Bill, Matthew
    Li, Chenglong
    Fuchs, Jim
    Kulp, Samuel
    Ihnat, Michael
    Lin, Jiayuh
    Hoyt, Dale
    Young, Gregory
    Carson, William
    Li, Pui-Kai
    CANCER RESEARCH, 2009, 69
  • [34] Inhibition of STAT3 prevents bone metastatic progression of prostate cancer in vivo
    Thulin, Malin Hagberg
    Maatta, Jorma
    Linder, Anna
    Sterbova, Simona
    Ohlsson, Claes
    Damber, Jan-Erik
    Widmark, Anders
    Persson, Emma
    PROSTATE, 2021, 81 (08): : 452 - 462
  • [35] Inhibition of curcumin on proliferation and invasion in giant cell tumor of bone (GCTB) by targeting STAT3
    Liu, Mingfa
    Tian, Shaopeng
    Liu, Yuanhang
    Gao, Feng
    Yin, Qingshui
    INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, 2016, 9 (11): : 21474 - 21481
  • [36] Lysophosphatidic acid induces STAT3 phosphorylation and ovarian cancer cell motility: Their inhibition by curcumin
    Seo, Ji Hye
    Jeong, Kang Jin
    Oh, Woo Jin
    Sul, Hae Jeong
    Sohn, Jang Sihn
    Kim, Yong Kee
    Cho, Do Yeun
    Kang, Jae Ku
    Park, Chang Gyo
    Lee, Hoi Young
    CANCER LETTERS, 2010, 288 (01) : 50 - 56
  • [37] Curcumin Suppresses M2 Macrophage-derived Paclitaxel Chemoresistance through Inhibition of PI3K-AKT/STAT3 Signaling
    Deswal, Bhawna
    Bagchi, Urmi
    Kapoor, Sonia
    ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY, 2024, 24 (02) : 146 - 156
  • [38] Inhibition of STAT3 activity delays obesity-induced thyroid carcinogenesis in a mouse model
    Park, Jeong Won
    Han, Cho Rong
    Zhao, Li
    Willingham, Mark C.
    Cheng, Sheue-yann
    ENDOCRINE-RELATED CANCER, 2016, 23 (01) : 53 - 63
  • [39] AhR and STAT3: A Dangerous Duo in Chemical Carcinogenesis
    Minacori, Marco
    Fiorini, Sara
    Perugini, Monia
    Iannetta, Annamaria
    Meschiari, Giorgia
    Chichiarelli, Silvia
    Altieri, Fabio
    Natali, Pier Giorgio
    Eufemi, Margherita
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2025, 26 (06)
  • [40] Inhibition of STAT3 reverses alkylator resistance through modulation of the AKT and β-catenin signaling pathways
    Wang, Yongzhi
    Chen, Lingchao
    Bao, Zhaoshi
    Li, Shouwei
    You, Gan
    Yan, Wei
    Shi, Zhendong
    Liu, Yanwei
    Yang, Pei
    Zhang, Wei
    Han, Lei
    Kang, Chunsheng
    Jiang, Tao
    ONCOLOGY REPORTS, 2011, 26 (05) : 1173 - 1180
12345