Lowest ever CD4 lymphocyte count (CD4 nadir) as a predictor of current cognitive and neurological status in human immunodeficiency virus type 1 infection—The Hawaii Aging with HIV Cohort

被引：0
|
作者：
Victor Valcour
Priscilla Yee
Andrew E. Williams
Bruce Shiramizu
Michael Watters
Ola Selnes
Robert Paul
Cecilia Shikuma
Ned Sacktor
机构：
[1] University of Hawaii,Hawaii AIDS Clinical Research Program
[2] University of Hawaii,John A. Burns School of Medicine
[3] Johns Hopkins University School of Medicine,Department of Psychology, Division of Behavioral Neuroscience
[4] University of Missouri,Office of Neurology and Aging Research, Sinclair 202
[5] Leahi Hospital,undefined
来源：
Journal of NeuroVirology | 2006年 / 12卷
关键词：
AIDS dementia complex; CD4 lymphocyte count; polyneuropathies;
D O I：
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中图分类号：
学科分类号：
摘要：
Low CD4 lymphocyte count was a marker for neurological disease in human immunodeficiency virus type 1 (HIV-1); but is now less common among patients with access to highly active antiretroviral therapy. In this study, the authors determine the reliability of self-reported CD4 nadir and its predictive value for neurological status. The authors identify a high degree of reliability (r = .90). After adjusting for age, current CD4 count, and duration of HIV-1, CD4 nadir relates to a current diagnosis of HIV-associated dimentia (HAD) (odds ratio [OR]: 1.395 (1.106–1.761), P = .005) and distal symmetric polyneuropathy (DSPN) (OR: 1.479 (1.221–1.769, P < .001).
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页码：387 / 391
页数：4
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