Lowest ever CD4 lymphocyte count (CD4 nadir) as a predictor of current cognitive and neurological status in human immunodeficiency virus type 1 infection—The Hawaii Aging with HIV Cohort

被引：0

作者：

Victor Valcour

Priscilla Yee

Andrew E. Williams

Bruce Shiramizu

Michael Watters

Ola Selnes

Robert Paul

Cecilia Shikuma

Ned Sacktor

机构：

[1] University of Hawaii,Hawaii AIDS Clinical Research Program

[2] University of Hawaii,John A. Burns School of Medicine

[3] Johns Hopkins University School of Medicine,Department of Psychology, Division of Behavioral Neuroscience

[4] University of Missouri,Office of Neurology and Aging Research, Sinclair 202

[5] Leahi Hospital,undefined

来源：

Journal of NeuroVirology | 2006年 / 12卷

关键词：

AIDS dementia complex; CD4 lymphocyte count; polyneuropathies;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Low CD4 lymphocyte count was a marker for neurological disease in human immunodeficiency virus type 1 (HIV-1); but is now less common among patients with access to highly active antiretroviral therapy. In this study, the authors determine the reliability of self-reported CD4 nadir and its predictive value for neurological status. The authors identify a high degree of reliability (r = .90). After adjusting for age, current CD4 count, and duration of HIV-1, CD4 nadir relates to a current diagnosis of HIV-associated dimentia (HAD) (odds ratio [OR]: 1.395 (1.106–1.761), P = .005) and distal symmetric polyneuropathy (DSPN) (OR: 1.479 (1.221–1.769, P < .001).

引用

页码：387 / 391

页数：4

共 50 条

[31] Correlation between total lymphocyte counts and CD4 among human immunodeficiency virus (HIV) patients
Darmana, I. M. S.
Rusni, N. W.
Masyeni, S.
3RD ANNUAL APPLIED SCIENCE AND ENGINEERING CONFERENCE (AASEC 2018), 2018, 197
[32] SOLUBLE CD4 MOLECULES NEUTRALIZE HUMAN IMMUNODEFICIENCY VIRUS TYPE-1
TRAUNECKER, A
LUKE, W
KARJALAINEN, K
NATURE, 1988, 331 (6151) : 84 - 86
[33] ANTIBODIES TO CD4 IN INDIVIDUALS INFECTED WITH HUMAN IMMUNODEFICIENCY VIRUS TYPE-1
KOWALSKI, M
ARDMAN, B
BASIRIPOUR, L
LU, YC
BLOHM, D
HASELTINE, W
SODROSKI, J
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (09) : 3346 - 3350
[34] Higher plasma CD4 lymphocyte count correlates with better cognitive function in human immunodeficiency virus-acquired immunodeficiency syndrome (HIV-AIDS) patients
Fitri, F. I.
Rambe, A. S.
Fitri, A.
1ST INT CONF ON TROP MED & INFECT DIS FAC OF MED UNIV SUMATERA UTARA IN CONJUNCTION WITH THE 23RD NATL CONGRESS OF THE INDONESIAN SOC OF TROP & INFECT DIS CONSULTANT AND THE 18TH ANNUAL MEETING OF INTERNAL MED DEPT FAC OF MED UNIV SUMATERA UTARA, 2018, 125
[35] Vitamin D Supplementation and CD4 Count in Children Infected with Human Immunodeficiency Virus
Kakalia, Spenta
Sochett, Etienne B.
Stephens, Derek
Assor, Esther
Read, Stanley E.
Bitnun, Ari
JOURNAL OF PEDIATRICS, 2011, 159 (06): : 951 - 957
[36] Correlation of Cardiac Autonomic Dysfunction with CD4 Count in Human Immunodeficiency Virus Patients
Badiger, Sharan
JOURNAL OF KRISHNA INSTITUTE OF MEDICAL SCIENCES UNIVERSITY, 2019, 8 (02) : 80 - 85
[37] Musculoskeletal manifestations in patients positive for human immunodeficiency virus:: Correlation with CD4 count
Casado, E
Olivé, A
Holgado, S
Perez-Andres, R
Romeu, J
Lorenzo, JC
Clotet, B
Tena, X
JOURNAL OF RHEUMATOLOGY, 2001, 28 (04) : 802 - 804
[38] CD4 Cell Count: A Critical Tool in the Human Immunodeficiency Virus Response COMMENT
Ford, Nathan
Chiller, Tom
CLINICAL INFECTIOUS DISEASES, 2022, 74 (08) : 1360 - 1361
[39] CHARACTERIZATION OF AUTOANTIBODIES TO THE CD4 MOLECULE IN HUMAN-IMMUNODEFICIENCY-VIRUS INFECTION
SEKIGAWA, I
GROOPMEN, JE
ALLAN, JD
IKEUCHI, K
BIBERFIELD, G
TAKATSUKI, K
BYRN, RA
CLINICAL IMMUNOLOGY AND IMMUNOPATHOLOGY, 1991, 58 (01): : 145 - 153
[40] CD4 EXPRESSION ON DENDRITIC CELLS AND THEIR INFECTION BY HUMAN-IMMUNODEFICIENCY-VIRUS
PATTERSON, S
GROSS, J
ENGLISH, N
STACKPOOLE, A
BEDFORD, P
KNIGHT, SC
JOURNAL OF GENERAL VIROLOGY, 1995, 76 : 1155 - 1163

← 1 2 3 4 5 →