Lowest ever CD4 lymphocyte count (CD4 nadir) as a predictor of current cognitive and neurological status in human immunodeficiency virus type 1 infection—The Hawaii Aging with HIV Cohort

被引：0

作者：

Victor Valcour

Priscilla Yee

Andrew E. Williams

Bruce Shiramizu

Michael Watters

Ola Selnes

Robert Paul

Cecilia Shikuma

Ned Sacktor

机构：

[1] University of Hawaii,Hawaii AIDS Clinical Research Program

[2] University of Hawaii,John A. Burns School of Medicine

[3] Johns Hopkins University School of Medicine,Department of Psychology, Division of Behavioral Neuroscience

[4] University of Missouri,Office of Neurology and Aging Research, Sinclair 202

[5] Leahi Hospital,undefined

来源：

Journal of NeuroVirology | 2006年 / 12卷

关键词：

AIDS dementia complex; CD4 lymphocyte count; polyneuropathies;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Low CD4 lymphocyte count was a marker for neurological disease in human immunodeficiency virus type 1 (HIV-1); but is now less common among patients with access to highly active antiretroviral therapy. In this study, the authors determine the reliability of self-reported CD4 nadir and its predictive value for neurological status. The authors identify a high degree of reliability (r = .90). After adjusting for age, current CD4 count, and duration of HIV-1, CD4 nadir relates to a current diagnosis of HIV-associated dimentia (HAD) (odds ratio [OR]: 1.395 (1.106–1.761), P = .005) and distal symmetric polyneuropathy (DSPN) (OR: 1.479 (1.221–1.769, P < .001).

引用

页码：387 / 391

页数：4

共 50 条

[1] Lowest ever CD4 lymphocyte count (CD4 nadir) as a predictor of current cognitive and neurological status in human immunodeficiency virus type 1 infection - The Hawaii Aging with HIV Cohort
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Yee, Priscilla
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Watters, Michael
Selnes, Ola
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