The Molecular Chaperone α-Crystallin as an Excipient in an Insulin Formulation

被引:0
|
作者
Tue Rasmussen
Ruedeeporn Tantipolphan
Marco van de Weert
Wim Jiskoot
机构
[1] University of Copenhagen,Faculty of Pharmaceutical Sciences
[2] Leiden University,Division of Drug Delivery Technology, Leiden Amsterdam Center for Drug Research
来源
Pharmaceutical Research | 2010年 / 27卷
关键词
fibrillation; formulation design; insulin; protein excipients; α-crystallin;
D O I
暂无
中图分类号
学科分类号
摘要
引用
收藏
页码:1337 / 1347
页数:10
相关论文
共 50 条
  • [41] Interactive Domains in the Molecular Chaperone Human αB Crystallin Modulate Microtubule Assembly and Disassembly
    Ghosh, Joy G.
    Houck, Scott A.
    Clark, John I.
    PLOS ONE, 2007, 2 (06):
  • [42] Role of ATP on the interaction of α-crystallin with its substrates and its implications for the molecular chaperone function
    Biswas, A
    Das, KP
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (41) : 42648 - 42657
  • [43] Association of partially folded lens βB2-crystallins with the α-crystallin molecular chaperone
    Evans, Paul
    Slingsby, Christine
    Wallace, B. A.
    BIOCHEMICAL JOURNAL, 2008, 409 : 691 - 699
  • [44] Binding of the Molecular Chaperone αB-Crystallin to Aβ Amyloid Fibrils Inhibits Fibril Elongation
    Shammas, Sarah L.
    Waudby, Christopher A.
    Wang, Shuyu
    Buell, Alexander K.
    Knowles, Tuomas P. J.
    Ecroyd, Heath
    Welland, Mark E.
    Carver, John A.
    Dobson, Christopher M.
    Meehan, Sarah
    BIOPHYSICAL JOURNAL, 2011, 101 (07) : 1681 - 1689
  • [45] The molecular chaperone alpha-crystallin inhibits UV-induced protein aggregation
    Borkman, RF
    Knight, G
    Obi, B
    EXPERIMENTAL EYE RESEARCH, 1996, 62 (02) : 141 - 148
  • [46] Human alpha B-crystallin - Small heat shock protein and molecular chaperone
    Muchowski, PJ
    Bassuk, JA
    Lubsen, NH
    Clark, JI
    JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (04) : 2578 - 2582
  • [47] ALPHA-CRYSTALLIN QUATERNARY STRUCTURE - MOLECULAR-BASIS FOR ITS CHAPERONE ACTIVITY
    SINGH, K
    GROTHVASSELLI, B
    KUMOSINSKI, TF
    FARNSWORTH, PN
    FEBS LETTERS, 1995, 372 (2-3) : 283 - 287
  • [48] Interactive sequences in the molecular chaperone, human αB crystallin modulate the fibrillation of amyloidogenic proteins
    Ghosh, Joy G.
    Houck, Scott A.
    Clark, John I.
    INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 2008, 40 (05): : 954 - 967
  • [49] Differential recognition of natural and nonnatural substrate by molecular chaperone α-crystallin -: A subunit exchange study
    Biswas, Ashis
    Das, K. P.
    BIOPOLYMERS, 2007, 85 (02) : 189 - 197
  • [50] PHOTODEGRADATION OF TRYPTOPHAN RESIDUES AND ATTENUATION OF MOLECULAR CHAPERONE ACTIVITY IN ALPHA-CRYSTALLIN ARE CORRELATED
    SCHAUERTE, JA
    GAFNI, A
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1995, 212 (03) : 900 - 905