Neutralization of SARS-CoV-2 spike 69/70 deletion, E484K and N501Y variants by BNT162b2 vaccine-elicited sera

被引：0
|
作者：
Xuping Xie
Yang Liu
Jianying Liu
Xianwen Zhang
Jing Zou
Camila R. Fontes-Garfias
Hongjie Xia
Kena A. Swanson
Mark Cutler
David Cooper
Vineet D. Menachery
Scott C. Weaver
Philip R. Dormitzer
Pei-Yong Shi
机构：
[1] University of Texas Medical Branch,Department of Biochemistry and Molecular Biology
[2] University of Texas Medical Branch,Departments of Microbiology and Immunology
[3] University of Texas Medical Branch,Institute for Human Infection and Immunity
[4] Pfizer,Institute for Translational Sciences
[5] University of Texas Medical Branch,Sealy Institute for Vaccine Sciences
[6] University of Texas Medical Branch,Sealy Center for Structural Biology & Molecular Biophysics
[7] University of Texas Medical Branch,undefined
来源：
Nature Medicine | 2021年 / 27卷
关键词：
D O I：
暂无
中图分类号：
学科分类号：
摘要：
We engineered three severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viruses containing key spike mutations from the newly emerged United Kingdom (UK) and South African (SA) variants: N501Y from UK and SA; 69/70-deletion + N501Y + D614G from UK; and E484K + N501Y + D614G from SA. Neutralization geometric mean titers (GMTs) of 20 BTN162b2 vaccine-elicited human sera against the three mutant viruses were 0.81- to 1.46-fold of the GMTs against parental virus, indicating small effects of these mutations on neutralization by sera elicited by two BNT162b2 doses.
引用
收藏
页码：620 / 621
页数：1
相关论文
共 50 条
  • [31] SARS-CoV-2 N501Y variants of concern and their potential transmission by mouse
    Hongyan Huang
    Yichao Zhu
    Zubiao Niu
    Lulin Zhou
    Qiang Sun
    Cell Death & Differentiation, 2021, 28 : 2840 - 2842
  • [32] SARS-CoV-2 N501Y variants of concern and their potential transmission by mouse
    Huang, Hongyan
    Zhu, Yichao
    Niu, Zubiao
    Zhou, Lulin
    Sun, Qiang
    CELL DEATH AND DIFFERENTIATION, 2021, 28 (10): : 2840 - 2842
  • [33] Exploring the Interaction between E484K and N501Y Substitutions of SARS-CoV-2 in Shaping the Transmission Advantage of COVID-19 in Brazil: A Modeling Study
    Zhao, Shi
    Ran, Jinjun
    Han, Lefei
    AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 2021, 105 (05): : 1247 - 1254
  • [34] Experience with SARS-CoV-2 BNT162b2 mRNA vaccine in dialysis patients
    Yanay, Noa Berar
    Freiman, Sarit
    Shapira, Ma'anit
    Wishahi, Samar
    Hamze, Munir
    Elhaj, Mohamad
    Zaher, Maha
    Armaly, Zaher
    KIDNEY INTERNATIONAL, 2021, 99 (06) : 1496 - 1498
  • [35] Herpes zoster infection following SARS-CoV-2 vaccine BNT162b2
    Lauro, Wanda
    Cillo, Francesco
    Nastro, Francesca
    Fabbrocini, Gabriella
    Marasca, Claudio
    ITALIAN JOURNAL OF DERMATOLOGY AND VENEREOLOGY, 2023, 158 (04) : 364 - 365
  • [36] Impact of SARS-CoV-2 Omicron variants on serum neutralization in a cohort of healthcare workers vaccinated with BNT162b2
    Gidari, Anna
    Schiaroli, Elisabetta
    Sabbatini, Samuele
    Bastianelli, Sabrina
    Pierucci, Sara
    Busti, Chiara
    Francisci, Daniela
    JOURNAL OF INFECTION, 2022, 85 (05) : E125 - E126
  • [37] Correlates of protection for booster doses of the SARS-CoV-2 vaccine BNT162b2
    Tomer Hertz
    Shlomia Levy
    Daniel Ostrovsky
    Hanna Oppenheimer
    Shosh Zismanov
    Alona Kuzmina
    Lilach M. Friedman
    Sanja Trifkovic
    David Brice
    Lin Chun-Yang
    Liel Cohen-Lavi
    Yonat Shemer-Avni
    Merav Cohen-Lahav
    Doron Amichay
    Ayelet Keren-Naus
    Olga Voloshin
    Gabriel Weber
    Ronza Najjar-Debbiny
    Bibiana Chazan
    Maureen A. McGargill
    Richard Webby
    Michal Chowers
    Lena Novack
    Victor Novack
    Ran Taube
    Lior Nesher
    Orly Weinstein
    Nature Communications, 14
  • [38] Partial resistance of SARS-CoV-2 Delta variants to vaccine-elicited antibodies and convalescent sera
    Tada, Takuya
    Zhou, Hao
    Dcosta, Belinda M.
    Samanovic, Marie, I
    Mulligan, Mark J.
    Landau, Nathaniel R.
    ISCIENCE, 2021, 24 (11)
  • [39] Correlates of protection for booster doses of the SARS-CoV-2 vaccine BNT162b2
    Hertz, Tomer
    Levy, Shlomia
    Ostrovsky, Daniel
    Oppenheimer, Hanna
    Zismanov, Shosh
    Kuzmina, Alona
    Friedman, Lilach M.
    Trifkovic, Sanja
    Brice, David
    Chun-Yang, Lin
    Cohen-Lavi, Liel
    Shemer-Avni, Yonat
    Cohen-Lahav, Merav
    Amichay, Doron
    Keren-Naus, Ayelet
    Voloshin, Olga
    Weber, Gabriel
    Najjar-Debbiny, Ronza
    Chazan, Bibiana
    McGargill, Maureen A.
    Webby, Richard
    Chowers, Michal
    Novack, Lena
    Novack, Victor
    Taube, Ran
    Nesher, Lior
    Weinstein, Orly
    NATURE COMMUNICATIONS, 2023, 14 (01)
  • [40] Immunity evasion: consequence of the N501Y mutation of the SARS-CoV-2 spike glycoprotein
    Henrietta Onyinye Uzoeto
    Judith Nnedimkpa Ajima
    Amarachukwu Vivian Arazu
    Glory Omini Ibiang
    Samuel Cosmas
    Olanrewaju Ayodeji Durojaye
    Journal of Genetic Engineering and Biotechnology, 20
12345