Neutralization of SARS-CoV-2 spike 69/70 deletion, E484K and N501Y variants by BNT162b2 vaccine-elicited sera

被引：0
|
作者：
Xuping Xie
Yang Liu
Jianying Liu
Xianwen Zhang
Jing Zou
Camila R. Fontes-Garfias
Hongjie Xia
Kena A. Swanson
Mark Cutler
David Cooper
Vineet D. Menachery
Scott C. Weaver
Philip R. Dormitzer
Pei-Yong Shi
机构：
[1] University of Texas Medical Branch,Department of Biochemistry and Molecular Biology
[2] University of Texas Medical Branch,Departments of Microbiology and Immunology
[3] University of Texas Medical Branch,Institute for Human Infection and Immunity
[4] Pfizer,Institute for Translational Sciences
[5] University of Texas Medical Branch,Sealy Institute for Vaccine Sciences
[6] University of Texas Medical Branch,Sealy Center for Structural Biology & Molecular Biophysics
[7] University of Texas Medical Branch,undefined
来源：
Nature Medicine | 2021年 / 27卷
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摘要：
We engineered three severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viruses containing key spike mutations from the newly emerged United Kingdom (UK) and South African (SA) variants: N501Y from UK and SA; 69/70-deletion + N501Y + D614G from UK; and E484K + N501Y + D614G from SA. Neutralization geometric mean titers (GMTs) of 20 BTN162b2 vaccine-elicited human sera against the three mutant viruses were 0.81- to 1.46-fold of the GMTs against parental virus, indicating small effects of these mutations on neutralization by sera elicited by two BNT162b2 doses.
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页码：620 / 621
页数：1
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