Evidence for Diminished Functional Expression of Intestinal Transporters in Caco-2 Cell Monolayers at High Passages

被引：0
|
作者：
Hongshi Yu
Thomas J. Cook
Patrick J. Sinko
机构：
[1] Rutgers University,College of Pharmacy
[2] NaviCyte,undefined
[3] Inc.,undefined
来源：
Pharmaceutical Research | 1997年 / 14卷
关键词：
aqueous boundary layer; brush border enzymes; carrier-mediated transport; diffusion chamber; heterogeneity; permeability;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Purpose. To investigate the effects of passaging on the intrinsic membrane transport parameters of compounds absorbed by means of passive and carrier-mediated processes in the Caco-2 cell line.
引用
收藏
页码：757 / 762
页数：5
相关论文
共 50 条
  • [41] Intestinal Permeability Study of Clinically Relevant Formulations of Silibinin in Caco-2 Cell Monolayers
    Perez-Sanchez, Almudena
    Cuyas, Elisabet
    Ruiz-Torres, Veronica
    Agullo-Chazarra, Luz
    Verdura, Sara
    Gonzalez-Alvarez, Isabel
    Bermejo, Marival
    Joven, Jorge
    Micol, Vicente
    Bosch-Barrera, Joaquim
    Menendez, Javier A.
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2019, 20 (07)
  • [42] Effects of Food Lectins on the Transport System of Human Intestinal Caco-2 Cell Monolayers
    Yamamoto, Shintaro
    Tomiyama, Mai
    Nemoto, Ryo
    Naganuma, Takako
    Ogawa, Tomohisa
    Muramoto, Koji
    BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 2013, 77 (09) : 1917 - 1924
  • [43] The Caco-2 cell line as a model of the intestinal barrier: influence of cell and culture-related factors on Caco-2 cell functional characteristics
    Sambuy, Y
    Angelis, I
    Ranaldi, G
    Scarino, ML
    Stammati, A
    Zucco, F
    CELL BIOLOGY AND TOXICOLOGY, 2005, 21 (01) : 1 - 26
  • [44] The Caco-2 cell line as a model of the intestinal barrier: influence of cell and culture-related factors on Caco-2 cell functional characteristics
    Y. Sambuy
    I. De Angelis
    G. Ranaldi
    M. L. Scarino
    A. Stammati
    F. Zucco
    Cell Biology and Toxicology, 2005, 21 : 1 - 26
  • [45] Transepithelial taurine transport in Caco-2 cell monolayers
    Roig-Pérez, S
    Moretó, M
    Ferrer, R
    JOURNAL OF MEMBRANE BIOLOGY, 2005, 204 (02): : 85 - 92
  • [46] Transport of curcumin derivatives in Caco-2 cell monolayers
    Zeng, Zhen
    Shen, Zhe L.
    Zhai, Shuo
    Xu, Jia L.
    Liang, Hui
    Shen, Qin
    Li, Qing Y.
    EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, 2017, 117 : 123 - 131
  • [47] Cytotoxicity of absorption enhancers in Caco-2 cell monolayers
    Sakai, M
    Imai, T
    Ohtake, H
    Otagiri, M
    JOURNAL OF PHARMACY AND PHARMACOLOGY, 1998, 50 (10) : 1101 - 1108
  • [48] Transepithelial Taurine Transport in Caco-2 Cell Monolayers
    S. Roig-Pérez
    M. Moretó
    R. Ferrer
    The Journal of Membrane Biology, 2005, 204 : 85 - 92
  • [49] Comparison of bidirectional cephalexin transport across MDCK and Caco-2 cell monolayers: Interactions with peptide transporters
    Putnam, WS
    Pan, L
    Tsutsui, K
    Takahashi, L
    Benet, LZ
    PHARMACEUTICAL RESEARCH, 2002, 19 (01) : 27 - 33
  • [50] Comparison of Bidirectional Cephalexin Transport Across MDCK and Caco-2 Cell Monolayers: Interactions with Peptide Transporters
    Wendy S. Putnam
    Lin Pan
    Ken Tsutsui
    Lori Takahashi
    Leslie Z. Benet
    Pharmaceutical Research, 2002, 19 : 27 - 33
12345