Targeting the metabolic vulnerability of acute myeloid leukemia blasts with a combination of venetoclax and 8-chloro-adenosine

被引:0
|
作者
Ralf Buettner
Le Xuan Truong Nguyen
Corey Morales
Min-Hsuan Chen
Xiwei Wu
Lisa S. Chen
Dinh Hoa Hoang
Servando Hernandez Vargas
Vinod Pullarkat
Varsha Gandhi
Guido Marcucci
Steven T. Rosen
机构
[1] City of Hope Medical Center,Hematology Malignancies Research Institute, Gehr Family Center for Leukemia Research
[2] City of Hope Medical Center,Integrative Genomics Core, Beckman Research Institute
[3] The University of Texas MD Anderson Cancer Center,Department of Experimental Therapeutics
关键词
Acute myeloid leukemia; Oxidative phosphorylation; Fatty acid oxidation; Nucleoside analog; Metabolism;
D O I
暂无
中图分类号
学科分类号
摘要
引用
收藏
相关论文
共 50 条
  • [11] Metabolic and mechanistic aspects of 8-chloro-adenosine and 8-chloro-cAMP-mediated cytotoxicity in multiple myeloma cells.
    Gandi, V
    Ayres, M
    Krett, NL
    Rosen, ST
    CLINICAL CANCER RESEARCH, 1999, 5 : 3838S - 3838S
  • [12] Targeting Sumoylation Sensitizes Acute Myeloid Leukemia to Venetoclax Treatment
    Du, Li
    Guo, Jiamin
    Chen, Zhenhua
    Chen, Jianjun
    Marcucci, Guido
    Rosen, Steven T.
    BLOOD, 2023, 142
  • [13] Venetoclax efficacy on acute myeloid leukemia is enhanced by the combination with butyrate
    Kawakatsu, Renshi
    Tadagaki, Kenjiro
    Yamasaki, Kenta
    Yoshida, Tatsushi
    SCIENTIFIC REPORTS, 2024, 14 (01)
  • [14] Venetoclax-Based Combination Regimens in Acute Myeloid Leukemia
    Goulart, Hannah
    Kantarjian, Hagop
    Pemmaraju, Naveen
    Daver, Naval
    Dinardo, Courtney D.
    Rausch, Caitlin R.
    Ravandi, Farhad
    Kadia, Tapan M.
    BLOOD CANCER DISCOVERY, 2025, 6 (01): : 23 - 37
  • [15] Venetoclax Combination Therapy in Relapsed/Refractory Acute Myeloid Leukemia
    Brancati, Serena
    Gozzo, Lucia
    Romano, Giovanni Luca
    Vetro, Calogero
    Dulcamare, Ilaria
    Maugeri, Cinzia
    Parisi, Marina
    Longo, Laura
    Vitale, Daniela Cristina
    Di Raimondo, Francesco
    Drago, Filippo
    BLOOD, 2021, 138
  • [16] Venetoclax combination therapy in acute myeloid leukemia and myelodysplastic syndromes
    Shimony, Shai
    Stone, Richard M.
    Stahl, Maximilian
    CURRENT OPINION IN HEMATOLOGY, 2022, 29 (02) : 63 - 73
  • [17] Venetoclax efficacy on acute myeloid leukemia is enhanced by the combination with butyrate
    Renshi Kawakatsu
    Kenjiro Tadagaki
    Kenta Yamasaki
    Tatsushi Yoshida
    Scientific Reports, 14
  • [18] Targeting metabolic vulnerabilities in acute myeloid leukemia
    Hameed, Kanwal Mahmood
    Emadi, Ashkan
    CANCER RESEARCH, 2023, 83 (07)
  • [19] Targeting Metabolic Reprogramming in Acute Myeloid Leukemia
    Castro, Isabel
    Sampaio-Marques, Belem
    Ludovico, Paula
    CELLS, 2019, 8 (09)
  • [20] Pharmacological targeting of β-catenin in normal karyotype acute myeloid leukemia blasts
    Griffiths, Elizabeth A.
    Golding, Michelle C.
    Srivastava, Pragya
    Povinelli, Benjamin J.
    James, Smitha R.
    Ford, Laurie A.
    Wetzler, Meir
    Wang, Eunice S.
    Nemeth, Michael J.
    HAEMATOLOGICA, 2015, 100 (02) : E49 - E52