Epistasis: too often neglected in complex trait studies?

被引：0
|
作者：
Örjan Carlborg
Chris S. Haley
机构：
[1] Linnaeus Centre for Bioinformatics,Department of Genetics and Biometry
[2] Uppsala University,undefined
[3] BMC,undefined
[4] Box 598,undefined
[5] Roslin Institute,undefined
[6] Roslin,undefined
来源：
Nature Reviews Genetics | 2004年 / 5卷
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学科分类号：
摘要：
Interactions among loci or between genes and environmental factors make a substantial contribution to variation in complex traits such as disease susceptibility. Nonetheless, many studies that attempt to identify the genetic basis of complex traits ignore the possibility that loci interact. We argue that epistasis should be accounted for in complex trait studies; we critically assess current study designs for detecting epistasis and discuss how these might be adapted for use in additional populations, including humans.
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页码：618 / 625
页数：7
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