COVID-19 has rapidly spread all over the world, progressing into a pandemic. This situation has urgently impelled many companies and public research institutes to concentrate their efforts on research for effective therapeutics. Here, we outline the strategies and targets currently adopted in developing a vaccine against SARS-CoV-2. Based on previous evidence and experience with SARS and MERS, the primary focus has been the Spike protein, considered as the ideal target for COVID-19 immunotherapies.
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Natl Res Council Canada, Metrol, 1200 Montreal Rd, Ottawa, ON K1A 0R6, CanadaNatl Res Council Canada, Metrol, 1200 Montreal Rd, Ottawa, ON K1A 0R6, Canada
Stocks, Bradley B.
Thibeault, Marie-Pier
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Natl Res Council Canada, Metrol, 1200 Montreal Rd, Ottawa, ON K1A 0R6, CanadaNatl Res Council Canada, Metrol, 1200 Montreal Rd, Ottawa, ON K1A 0R6, Canada
Thibeault, Marie-Pier
Schrag, Joseph D.
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Natl Res Council Canada, Human Hlth Therapeut, 6100 Royalmount Ave, Montreal, PQ H4P 2R2, CanadaNatl Res Council Canada, Metrol, 1200 Montreal Rd, Ottawa, ON K1A 0R6, Canada
Schrag, Joseph D.
Melanson, Jeremy E.
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Natl Res Council Canada, Metrol, 1200 Montreal Rd, Ottawa, ON K1A 0R6, CanadaNatl Res Council Canada, Metrol, 1200 Montreal Rd, Ottawa, ON K1A 0R6, Canada
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Boston Childrens Hosp, Div Mol Med, Boston, MA 02115 USA
Harvard Med Sch, Dept Pediat, Boston, MA 02115 USABoston Childrens Hosp, Div Mol Med, Boston, MA 02115 USA
Cai, Yongfei
Zhang, Jun
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Boston Childrens Hosp, Div Mol Med, Boston, MA 02115 USA
Harvard Med Sch, Dept Pediat, Boston, MA 02115 USABoston Childrens Hosp, Div Mol Med, Boston, MA 02115 USA
Zhang, Jun
Xiao, Tianshu
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Boston Childrens Hosp, Div Mol Med, Boston, MA 02115 USA
Harvard Med Sch, Dept Pediat, Boston, MA 02115 USABoston Childrens Hosp, Div Mol Med, Boston, MA 02115 USA
Xiao, Tianshu
Peng, Hanqin
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Boston Childrens Hosp, Div Mol Med, Boston, MA 02115 USABoston Childrens Hosp, Div Mol Med, Boston, MA 02115 USA
Peng, Hanqin
Sterling, Sarah M.
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Harvard Med Sch, Harvard CryoEM Ctr Struct Biol, Boston, MA 02115 USA
Harvard Med Sch, Blavatnik Inst, Dept Biol Chem & Mol Pharmacol, Boston, MA 02115 USABoston Childrens Hosp, Div Mol Med, Boston, MA 02115 USA
Sterling, Sarah M.
Walsh, Richard M., Jr.
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Harvard Med Sch, Harvard CryoEM Ctr Struct Biol, Boston, MA 02115 USA
Harvard Med Sch, Blavatnik Inst, Dept Biol Chem & Mol Pharmacol, Boston, MA 02115 USABoston Childrens Hosp, Div Mol Med, Boston, MA 02115 USA
Walsh, Richard M., Jr.
Rawson, Shaun
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Harvard Med Sch, Harvard CryoEM Ctr Struct Biol, Boston, MA 02115 USA
Harvard Med Sch, Blavatnik Inst, Dept Biol Chem & Mol Pharmacol, Boston, MA 02115 USA
Harvard Med Sch, SBGrid Consortium, Boston, MA 02115 USABoston Childrens Hosp, Div Mol Med, Boston, MA 02115 USA
Rawson, Shaun
Rits-Volloch, Sophia
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Boston Childrens Hosp, Div Mol Med, Boston, MA 02115 USABoston Childrens Hosp, Div Mol Med, Boston, MA 02115 USA
Rits-Volloch, Sophia
Chen, Bing
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Boston Childrens Hosp, Div Mol Med, Boston, MA 02115 USA
Harvard Med Sch, Dept Pediat, Boston, MA 02115 USABoston Childrens Hosp, Div Mol Med, Boston, MA 02115 USA