SARS-CoV-2 SPIKE PROTEIN: an optimal immunological target for vaccines

被引：0
|
作者：
Giovanni Salvatori
Laura Luberto
Mariano Maffei
Luigi Aurisicchio
Giuseppe Roscilli
Fabio Palombo
Emanuele Marra
机构：
[1] Takis s.r.l,
[2] Evvivax s.r.l,undefined
来源：
Journal of Translational Medicine | / 18卷
关键词：
SARS-CoV-2; SPIKE protein; Vaccine;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
COVID-19 has rapidly spread all over the world, progressing into a pandemic. This situation has urgently impelled many companies and public research institutes to concentrate their efforts on research for effective therapeutics. Here, we outline the strategies and targets currently adopted in developing a vaccine against SARS-CoV-2. Based on previous evidence and experience with SARS and MERS, the primary focus has been the Spike protein, considered as the ideal target for COVID-19 immunotherapies.
引用
收藏
相关论文
共 50 条
  • [21] Is the Stalk of the SARS-CoV-2 Spike Protein Druggable?
    Pipito, Ludovico
    Reynolds, Christopher A.
    Deganutti, Giuseppe
    VIRUSES-BASEL, 2022, 14 (12):
  • [22] Allosteric regulation in SARS-CoV-2 spike protein
    Wei, Yong
    Chen, Amy X.
    Lin, Yuewei
    Wei, Tao
    Qiao, Baofu
    PHYSICAL CHEMISTRY CHEMICAL PHYSICS, 2024, 26 (08) : 6582 - 6589
  • [23] SARS-CoV-2 spike protein allays pain
    Sekhar, Jerin
    Passi, Gouri Rao
    INDIAN PEDIATRICS, 2020, 57 (11) : 1091 - 1091
  • [24] The roles of glycans in the SARS-CoV-2 spike protein
    Casalino, Lorenzo
    Amaro, Rommie E.
    BIOPHYSICAL JOURNAL, 2022, 121 (03) : 459A - 460A
  • [25] Mutations and Evolution of the SARS-CoV-2 Spike Protein
    Magazine, Nicholas
    Zhang, Tianyi
    Wu, Yingying
    McGee, Michael C.
    Veggiani, Gianluca
    Huang, Weishan
    VIRUSES-BASEL, 2022, 14 (03):
  • [26] Biomimetic SARS-CoV-2 Spike Protein Nanoparticles
    Phan, Alvin
    Avila, Hugo
    MacKay, J. Andrew
    BIOMACROMOLECULES, 2023, 24 (05) : 2030 - 2041
  • [27] Binding of the SARS-CoV-2 spike protein to glycans
    Hao, Wei
    Ma, Bo
    Li, Ziheng
    Wang, Xiaoyu
    Gao, Xiaopan
    Li, Yaohao
    Qin, Bo
    Shang, Shiying
    Cui, Sheng
    Tan, Zhongping
    SCIENCE BULLETIN, 2021, 66 (12) : 1205 - 1214
  • [28] Cellular microRNAs target SARS-CoV-2 spike protein and restrict viral replication
    Vaddadi, Kishore
    Gandikota, Chaitanya
    Huang, Chaoqun
    Liang, Yurong
    Liu, Lin
    AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 2023, 325 (02): : C420 - C428
  • [29] SARS-CoV-2 spike protein: a key target for eliciting persistent neutralizing antibodies
    Yang Yang
    Lanying Du
    Signal Transduction and Targeted Therapy, 6
  • [30] SARS-CoV-2 spike protein: a key target for eliciting persistent neutralizing antibodies
    Yang, Yang
    Du, Lanying
    SIGNAL TRANSDUCTION AND TARGETED THERAPY, 2021, 6 (01)
12345