Subretinal gene delivery using helper-dependent adenoviral vectors

被引：0
|
作者：
Linda Wu
Simon Lam
Huibi Cao
Rui Guan
Rongqi Duan
Derek van der Kooy
Rod Bremner
Robert S Molday
Jim Hu
机构：
[1] Hospital for Sick Children,Physiology and Experimental Medicine Program
[2] University of Toronto,Department of Laboratory Medicine and Pathobiology
[3] University of Toronto,Department of Paediatrics
[4] University of Toronto,Department of Molecular Genetics
[5] University Health Network,Toronto Western Research Institute
[6] University of Toronto,Department of Biochemistry and Molecular Biology
[7] 2350 Health Sciences Mall,undefined
[8] University of British Columbia,undefined
来源：
Cell & Bioscience | / 1卷
关键词：
Retinal Pigment Epithelial; Gene Therapy Trial; Retinal Pigment Epithelial Layer; Vector Dose; Subretinal Injection;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
This study describes the successful delivery of helper-dependent adenoviral vectors to the mouse retina with long term and robust levels of reporter expression in the retina without apparent adverse effects. Since these vectors have a large cloning capacity, they have great potential to extend the success of gene therapy achieved using the adeno-associated viral vector.
引用
收藏
相关论文
共 50 条
  • [21] Progress and prospects: gene therapy for genetic diseases with helper-dependent adenoviral vectors
    Brunetti-Pierri, N.
    Ng, P.
    GENE THERAPY, 2008, 15 (08) : 553 - 560
  • [22] Progress and prospects: gene therapy for genetic diseases with helper-dependent adenoviral vectors
    N Brunetti-Pierri
    P Ng
    Gene Therapy, 2008, 15 : 553 - 560
  • [23] Targeted gene correction in mouse embryonic stem cells using helper-dependent adenoviral vectors
    Ohbayashi, F
    Balamotis, MA
    Ko, M
    MOLECULAR THERAPY, 2004, 9 : S115 - S115
  • [24] Development of an inflammation-inducible gene expression system using helper-dependent adenoviral vectors
    Yang, Tianyao
    Duan, Rongqi
    Cao, Huibi
    Lee, Benjamin H.
    Xia, Chun
    Chang, Zhijie
    Tanswell, A. Keith
    Hu, Jim
    JOURNAL OF GENE MEDICINE, 2010, 12 (10): : 832 - 839
  • [25] Feasibility of Applying Helper-Dependent Adenoviral Vectors for Cancer Immunotherapy
    Farzad, Lisa M.
    Suzuki, Masataka
    BIOMEDICINES, 2014, 2 (01): : 110 - 131
  • [26] Helper-dependent adenoviral vectors for inborn errors of liver metabolism
    Brunetti-Pierri, Nicola
    HUMAN GENE THERAPY, 2012, 23 (10) : A26 - A26
  • [27] Production of Helper-Dependent Adenoviral Vectors Using a Recombinase-Free System
    Cots, D.
    Alba, R.
    Segura, M. M.
    Ibanes, S.
    Ostapchuk, P.
    Kremer, E. J.
    Bosch, A.
    Hearing, P.
    Chillon, M.
    HUMAN GENE THERAPY, 2009, 20 (09) : 1089 - 1089
  • [28] Helper-dependent adenovirus vectors: their use as a gene delivery system to neurons
    Cregan, SP
    MacLaurin, J
    Gendron, TF
    Callaghan, SM
    Park, DS
    Parks, RJ
    Graham, FL
    Morley, P
    Slack, RS
    GENE THERAPY, 2000, 7 (14) : 1200 - 1209
  • [29] Helper-dependent adenovirus vectors: their use as a gene delivery system to neurons
    SP Cregan
    J MacLaurin
    TF Gendron
    SM Callaghan
    DS Park
    RJ Parks
    FL Graham
    P Morley
    RS Slack
    Gene Therapy, 2000, 7 : 1200 - 1209
  • [30] High-capacity, helper-dependent, "gutless" adenoviral vectors for gene transfer into brain
    Lowenstein, PR
    Thomas, CE
    Umana, P
    Gerdes, CA
    Verakis, T
    Boyer, O
    Tondeur, S
    Klatzmann, D
    Castro, MG
    GENE THERAPY METHODS, 2002, 346 : 292 - 311
12345