Subretinal gene delivery using helper-dependent adenoviral vectors

被引：0
|
作者：
Linda Wu
Simon Lam
Huibi Cao
Rui Guan
Rongqi Duan
Derek van der Kooy
Rod Bremner
Robert S Molday
Jim Hu
机构：
[1] Hospital for Sick Children,Physiology and Experimental Medicine Program
[2] University of Toronto,Department of Laboratory Medicine and Pathobiology
[3] University of Toronto,Department of Paediatrics
[4] University of Toronto,Department of Molecular Genetics
[5] University Health Network,Toronto Western Research Institute
[6] University of Toronto,Department of Biochemistry and Molecular Biology
[7] 2350 Health Sciences Mall,undefined
[8] University of British Columbia,undefined
来源：
Cell & Bioscience | / 1卷
关键词：
Retinal Pigment Epithelial; Gene Therapy Trial; Retinal Pigment Epithelial Layer; Vector Dose; Subretinal Injection;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
This study describes the successful delivery of helper-dependent adenoviral vectors to the mouse retina with long term and robust levels of reporter expression in the retina without apparent adverse effects. Since these vectors have a large cloning capacity, they have great potential to extend the success of gene therapy achieved using the adeno-associated viral vector.
引用
收藏
相关论文
共 50 条
  • [11] Pancreatic Transduction by Helper-Dependent Adenoviral Vectors via Intraductal Delivery
    Morro, Meritxell
    Teichenne, Joan
    Jimenez, Veronica
    Kratzer, Ramona
    Marletta, Serena
    Maggioni, Luca
    Mallol, Cristina
    Ruberte, Jesus
    Kochanek, Stefan
    Bosch, Fatima
    Ayuso, Eduard
    HUMAN GENE THERAPY, 2014, 25 (09) : 824 - 836
  • [12] Replication and packaging of helper-dependent adenoviral vectors
    Sato, M
    Suzuki, S
    Kubo, S
    Mitani, K
    GENE THERAPY, 2002, 9 (07) : 472 - 476
  • [13] Replication and packaging of helper-dependent adenoviral vectors
    M Sato
    S Suzuki
    S Kubo
    K Mitani
    Gene Therapy, 2002, 9 : 472 - 476
  • [14] Advantages of FISH far characterising delivery of helper-dependent adenoviral vectors for gene therapy.
    Bodamer, OA
    Mull, B
    Lee, B
    Beaudet, AL
    AMERICAN JOURNAL OF HUMAN GENETICS, 1999, 65 (04) : A116 - A116
  • [15] Helper-dependent adenoviral vectors for liver-directed gene therapy
    Brunetti-Pierri, Nicola
    Ng, Philip
    HUMAN MOLECULAR GENETICS, 2011, 20 : R7 - R13
  • [16] Robust Hepatic Gene Silencing for Functional Studies Using Helper-Dependent Adenoviral Vectors
    Ruiz, Rafaela
    Witting, Scott R.
    Saxena, Romil
    Morral, Nuria
    HUMAN GENE THERAPY, 2009, 20 (01) : 87 - 94
  • [17] Expanded-capacity adenoviral vectors - the helper-dependent vectors
    Morsy, MA
    Caskey, CT
    MOLECULAR MEDICINE TODAY, 1999, 5 (01): : 18 - 24
  • [18] Evaluating the tropism of chimeric helper-dependent adenoviral vectors for delivery of large genes
    Wiley, Luke A.
    Burnight, Erin R.
    Ochoa, Dalyz
    Collins, Malia M.
    Varzavand, Katayoun
    Stone, Edwin M.
    Mullins, Robert F.
    Tucker, Budd A.
    Han, Ian
    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2021, 62 (08)
  • [19] Generation of helper-dependent adenoviral vectors by homologous recombination
    Toietta, G
    Pastore, L
    Cerullo, V
    Finegold, M
    Beaudet, AL
    Lee, B
    MOLECULAR THERAPY, 2002, 5 (02) : 204 - 210
  • [20] Gene Therapy with Helper-Dependent Adenoviral Vectors: Current Advances and Future Perspectives
    Vetrini, Francesco
    Ng, Philip
    VIRUSES-BASEL, 2010, 2 (09): : 1886 - 1917
12345