Neuroprotective role of Sirt1 in mammalian models of Huntington's disease through activation of multiple Sirt1 targets

被引：0

作者：

Mali Jiang

Jiawei Wang

Jinrong Fu

Lin Du

Hyunkyung Jeong

Tim West

Lan Xiang

Qi Peng

Zhipeng Hou

Huan Cai

Tamara Seredenina

Nicolas Arbez

Shanshan Zhu

Katherine Sommers

Jennifer Qian

Jiangyang Zhang

Susumu Mori

X William Yang

Kellie L K Tamashiro

Susan Aja

Timothy H Moran

Ruth Luthi-Carter

Bronwen Martin

Stuart Maudsley

Mark P Mattson

Robert H Cichewicz

Christopher A Ross

David M Holtzman

Dimitri Krainc

Wenzhen Duan

机构：

[1] Johns Hopkins University School of Medicine,Division of Neurobiology, Department of Psychiatry and Behavioral Sciences

[2] Beijing Friendship Hospital,Department of Chemistry and Biochemistry

[3] Capital Medical University,Department of Neurology

[4] Natural Products Discovery Group,Department of Neurology and the Hope Center for Neurological Disorders

[5] University of Oklahoma,Department of Radiology

[6] MassGeneral Institute for Neurodegenerative Disease,Department of Psychiatry and Behavioral Sciences

[7] Massachusetts General Hospital,Department of Psychiatry and Behavioral Sciences

[8] Harvard Medical School,Department of Neuroscience

[9] Washington University School of Medicine,Department of Neurology

[10] Johns Hopkins University School of Medicine,Department of Pharmacology

[11] Metabolism Unit,undefined

[12] Laboratory of Clinical Investigation,undefined

[13] National Institute on Aging (NIA),undefined

[14] US National Institutes of Health (NIH),undefined

[15] Brain Mind Institute,undefined

[16] Ecole Polytechnique Fédérale de Lausanne,undefined

[17] Brain Research Institute,undefined

[18] University of California,undefined

[19] Johns Hopkins University School of Medicine,undefined

[20] Center for Metabolism and Obesity Research,undefined

[21] Johns Hopkins University School of Medicine,undefined

[22] Laboratory of Neurosciences,undefined

[23] NIA,undefined

[24] NIH,undefined

[25] Johns Hopkins University School of Medicine,undefined

[26] Johns Hopkins University School of Medicine,undefined

[27] Johns Hopkins University School of Medicine,undefined

[28] Program in Cellular and Molecular Medicine,undefined

[29] Johns Hopkins University School of Medicine,undefined

来源：

Nature Medicine | 2012年 / 18卷

关键词：

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Huntington's disease is a neurodegenerative disease caused by the accumulation of mutant htt protein. Now, two groups led by Dimitri Krainc and Wenzhen Duan report that mutant htt binds and inactivates the deacetylase enzyme SIRT1 and that SIRT1 overexpression is protective in Huntington's disease mouse models.

引用

页码：153 / 158

页数：5

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