Neuroprotective role of Sirt1 in mammalian models of Huntington's disease through activation of multiple Sirt1 targets

被引：0

作者：

Mali Jiang

Jiawei Wang

Jinrong Fu

Lin Du

Hyunkyung Jeong

Tim West

Lan Xiang

Qi Peng

Zhipeng Hou

Huan Cai

Tamara Seredenina

Nicolas Arbez

Shanshan Zhu

Katherine Sommers

Jennifer Qian

Jiangyang Zhang

Susumu Mori

X William Yang

Kellie L K Tamashiro

Susan Aja

Timothy H Moran

Ruth Luthi-Carter

Bronwen Martin

Stuart Maudsley

Mark P Mattson

Robert H Cichewicz

Christopher A Ross

David M Holtzman

Dimitri Krainc

Wenzhen Duan

机构：

[1] Johns Hopkins University School of Medicine,Division of Neurobiology, Department of Psychiatry and Behavioral Sciences

[2] Beijing Friendship Hospital,Department of Chemistry and Biochemistry

[3] Capital Medical University,Department of Neurology

[4] Natural Products Discovery Group,Department of Neurology and the Hope Center for Neurological Disorders

[5] University of Oklahoma,Department of Radiology

[6] MassGeneral Institute for Neurodegenerative Disease,Department of Psychiatry and Behavioral Sciences

[7] Massachusetts General Hospital,Department of Psychiatry and Behavioral Sciences

[8] Harvard Medical School,Department of Neuroscience

[9] Washington University School of Medicine,Department of Neurology

[10] Johns Hopkins University School of Medicine,Department of Pharmacology

[11] Metabolism Unit,undefined

[12] Laboratory of Clinical Investigation,undefined

[13] National Institute on Aging (NIA),undefined

[14] US National Institutes of Health (NIH),undefined

[15] Brain Mind Institute,undefined

[16] Ecole Polytechnique Fédérale de Lausanne,undefined

[17] Brain Research Institute,undefined

[18] University of California,undefined

[19] Johns Hopkins University School of Medicine,undefined

[20] Center for Metabolism and Obesity Research,undefined

[21] Johns Hopkins University School of Medicine,undefined

[22] Laboratory of Neurosciences,undefined

[23] NIA,undefined

[24] NIH,undefined

[25] Johns Hopkins University School of Medicine,undefined

[26] Johns Hopkins University School of Medicine,undefined

[27] Johns Hopkins University School of Medicine,undefined

[28] Program in Cellular and Molecular Medicine,undefined

[29] Johns Hopkins University School of Medicine,undefined

来源：

Nature Medicine | 2012年 / 18卷

关键词：

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Huntington's disease is a neurodegenerative disease caused by the accumulation of mutant htt protein. Now, two groups led by Dimitri Krainc and Wenzhen Duan report that mutant htt binds and inactivates the deacetylase enzyme SIRT1 and that SIRT1 overexpression is protective in Huntington's disease mouse models.

引用

页码：153 / 158

页数：5

共 50 条

[21] Sirt1 transgenic and cancer models
Serrano, Manuel
CANCER RESEARCH, 2011, 71
[22] AROuSing SIRT1: Identification of a novel endogenous SIRT1 activator
Verdin, Eric
MOLECULAR CELL, 2007, 28 (03) : 354 - 356
[23] The role of SIRT1 in kidney diseases
Wang, Wei
Hu, Yuanyuan
Ding, Ning
Wei, Jiping
Li, Cairong
INTERNATIONAL UROLOGY AND NEPHROLOGY, 2025, 57 (01) : 147 - 158
[24] Role of SIRT1 in homologous recombination
Uhl, Miriam
Csernok, Andreea
Aydin, Sevtap
Kreienberg, Rolf
Wiesmueller, Lisa
Gatz, Susanne Andrea
DNA REPAIR, 2010, 9 (04) : 383 - 393
[25] MICRORNA-455 TARGETS SIRT1
Swingler, T. E.
Wormstone, Y.
Lott, M.
Barter, M.
Young, D.
Clark, I. M.
OSTEOARTHRITIS AND CARTILAGE, 2015, 23 : A275 - A276
[26] The role of polydatin in inhibiting oxidative stress through SIRT1 activation: A comprehensive review of molecular targets
Liu, Ke
Liu, Jiaxi
Xu, Anjian
Ding, Junying
JOURNAL OF ETHNOPHARMACOLOGY, 2024, 331
[27] Role of SIRT1 in Chemoresistant Leukemia
Fajardo-Orduna, Guadalupe Rosario
Ledesma-Martinez, Edgar
Aguiniga-Sanchez, Itzen
Weiss-Steider, Benny
Santiago-Osorio, Edelmiro
Wiemer, Erik A. C.
Camacho-Arroyo, Ignacio
Melendez-Zajgla, Jorge
Valverde Ramirez, Mahara A.
Rodriguez-Dorantes, Mauricio
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2023, 24 (19)
[28] The role of SIRT1 in diabetic retinopathy
Karbasforooshan, Hedyieh
Karimi, Gholamreza
BIOMEDICINE & PHARMACOTHERAPY, 2018, 97 : 190 - 194
[29] SIRT1: Role in cardiovascular biology
Ma, Lina
Li, Yun
CLINICA CHIMICA ACTA, 2015, 440 : 8 - 15
[30] The role of SIRT1 in ocular aging
Mimura, Tatsuya
Kaji, Yuichi
Noma, Hidetaka
Funatsu, Hideharu
Okamoto, Shinseiro
EXPERIMENTAL EYE RESEARCH, 2013, 116 : 17 - 26

← 1 2 3 4 5 →