First Example of a Continuous-Flow Carbonylation Reaction Using Aryl Formates as CO Precursors

被引：0

作者：

Nerea Alonso

Juan M. de Muñoz

Brecht Egle

Johannes L. Vrijdag

Wim M. De Borggraeve

Antonio de la Hoz

Angel Díaz-Ortiz

Jesús Alcázar

机构：

[1] Department of Medicinal Chemistry,Department of Chemistry, Molecular Design and Synthesis

[2] Janssen Research and Development,Facultad de Ciencias y Tecnologías Químicas

[3] Janssen-Cilag,undefined

[4] S.A.,undefined

[5] University of Leuven,undefined

[6] Universidad de Castilla-La Mancha,undefined

来源：

Journal of Flow Chemistry | 2014年 / 4卷

关键词：

CO-free; carbonylation; flow chemistry; aryl formate; palladium;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

The first continuous flow carbonylation reaction using aryl formates as CO precursor is reported. The reaction is practical, scalable and high yielding. The use of a flow protocol safely allows expanding the scope to activated chlorides, nitrogen heterocycles and to the selective introduction of an ester group in dihalo-derivatives. Further selective reduction of the ester formed to an aldehyde in flow is also described.

引用

页码：105 / 109

页数：4

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