First Example of a Continuous-Flow Carbonylation Reaction Using Aryl Formates as CO Precursors

被引：0
|
作者：
Nerea Alonso
Juan M. de Muñoz
Brecht Egle
Johannes L. Vrijdag
Wim M. De Borggraeve
Antonio de la Hoz
Angel Díaz-Ortiz
Jesús Alcázar
机构：
[1] Department of Medicinal Chemistry,Department of Chemistry, Molecular Design and Synthesis
[2] Janssen Research and Development,Facultad de Ciencias y Tecnologías Químicas
[3] Janssen-Cilag,undefined
[4] S.A.,undefined
[5] University of Leuven,undefined
[6] Universidad de Castilla-La Mancha,undefined
来源：
Journal of Flow Chemistry | 2014年 / 4卷
关键词：
CO-free; carbonylation; flow chemistry; aryl formate; palladium;
D O I：
暂无
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学科分类号：
摘要：
The first continuous flow carbonylation reaction using aryl formates as CO precursor is reported. The reaction is practical, scalable and high yielding. The use of a flow protocol safely allows expanding the scope to activated chlorides, nitrogen heterocycles and to the selective introduction of an ester group in dihalo-derivatives. Further selective reduction of the ester formed to an aldehyde in flow is also described.
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页码：105 / 109
页数：4
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