Exosomes from adipose tissue-derived mesenchymal stem cells ameliorate histone-induced acute lung injury by activating the PI3K/Akt pathway in endothelial cells

被引：0
|
作者：
Yukie Mizuta
Tomohiko Akahoshi
Jie Guo
Shuo Zhang
Sayoko Narahara
Takahito Kawano
Masaharu Murata
Kentaro Tokuda
Masatoshi Eto
Makoto Hashizume
Ken Yamaura
机构：
[1] Kyushu University,Department of Disaster and Emergency Medicine, Graduate School of Medical Sciences
[2] Kyushu University,Department of Anesthesiology and Critical Care Medicine, Graduate School of Medical Sciences
[3] Kyushu University Hospital,Emergency and Critical Care Center
[4] Kyushu University,Center for Advanced Medical Innovation
[5] Kyushu University Hospital,Intensive Care Unit
来源：
Stem Cell Research & Therapy | / 11卷
关键词：
Sepsis; Acute lung injury; Acute respiratory distress syndrome; Histones; Endothelial damage; Adipose-derived mesenchymal stem cells; Exosomes; PI3K/Akt signaling pathway; miR-126;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
引用
收藏
相关论文
共 50 条
  • [31] Human umbilical cord mesenchymal stem cells derived exosomes exert antiapoptosis effect via activating PI3K/Akt/mTOR pathway on H9C2 cells
    Liu, Hui
    Sun, Xiaolu
    Gong, Xuhe
    Wang, Guogan
    JOURNAL OF CELLULAR BIOCHEMISTRY, 2019, 120 (09) : 14455 - 14464
  • [32] Exosomes derived from human umbilical cord mesenchymal stem cells alleviate acetaminophen-induced acute liver failure through activating ERK and IGF-1R/PI3K/AKT signaling pathway
    Wu, Han-You
    Zhang, Xiang-Cheng
    Jia, Bing-Bing
    Cao, Ye
    Yan, Kai
    Li, Jing-Yuan
    Tao, Li
    Jie, Zhi-Gang
    Liu, Quan-Wen
    JOURNAL OF PHARMACOLOGICAL SCIENCES, 2021, 147 (01) : 143 - 155
  • [33] Human amniotic mesenchymal stem cells-derived conditioned medium and exosomes alleviate oxidative stress-induced retinal degeneration by activating PI3K/Akt/FoxO3 pathway
    Peng, Zhe-Qing
    Guan, Xiao-Hui
    Yu, Zhen-Ping
    Wu, Jie
    Han, Xin-Hao
    Li, Ming-Hui
    Qu, Xin-Hui
    Chen, Zhi-Ping
    Han, Xiao-Jian
    Wang, Xiao-Yu
    EXPERIMENTAL EYE RESEARCH, 2024, 244
  • [34] Curcumin ameliorates heatstroke-induced lung injury by activating the PI3K/AKT pathway
    Wu, Yizhan
    Guo, Fei
    Li, Jiajia
    Shi, Wenhui
    Song, Laiyang
    Liu, Jiangwei
    NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 2025, 398 (04) : 4617 - 4632
  • [35] Overexpression of Wnt5a promoted the protective effect of mesenchymal stem cells on Lipopolysaccharide-induced endothelial cell injury via activating PI3K/AKT signaling pathway
    Manliang Guo
    Shiqi Li
    Chuan Li
    Xueyan Mao
    Liru Tian
    Xintong Yang
    Caixia Xu
    Mian Zeng
    BMC Infectious Diseases, 24
  • [36] Overexpression of Wnt5a promoted the protective effect of mesenchymal stem cells on Lipopolysaccharide-induced endothelial cell injury via activating PI3K/AKT signaling pathway
    Guo, Manliang
    Li, Shiqi
    Li, Chuan
    Mao, Xueyan
    Tian, Liru
    Yang, Xintong
    Xu, Caixia
    Zeng, Mian
    BMC INFECTIOUS DISEASES, 2024, 24 (01)
  • [37] Exosomes from adipose-derived stem cells activate sebocytes through the PI3K/AKT/SREBP-1 pathway to accelerate wound healing
    Zhang, Yingbo
    Zouboulis, Christos C.
    Xiao, Zhibo
    CELL AND TISSUE RESEARCH, 2024, 396 (03) : 329 - 342
  • [38] Exosomes from breast cancer cells can convert adipose tissue-derived mesenchymal stem cells into myofibroblast-like cells
    Cho, Jung Ah
    Park, Ho
    Lim, Eun Hye
    Lee, Kyo Won
    INTERNATIONAL JOURNAL OF ONCOLOGY, 2012, 40 (01) : 130 - 138
  • [39] Exosomes from Adipose Tissue-derived Mesenchymal Stem Cells Induce Regulatory T Cells in COVID-19 Patients
    Motallebnezhad, Morteza
    Hazrati, Ali
    Ghaleh, Hadi Esmaeili Gouvarchin
    Jonaidi-Jafari, Nematollah
    Abbaspour-Aghdam, Sanaz
    Malekpour, Kosar
    Yousefi, Mehdi
    Kafil, Hossein Samadi
    Jadidi-Niaragh, Farhad
    Roshangar, Leila
    Valizadeh, Hamed
    Izadi, Morteza
    Ahmadi, Majid
    IRANIAN JOURNAL OF ALLERGY ASTHMA AND IMMUNOLOGY, 2023, 22 (03) : 233 - 244
  • [40] Adipose tissue-derived stem cells attenuate acute lung injury through eNOS and eNOS-derived NO
    Gao, Peng
    Yang, Xu
    Mungur, Luckshmanraj
    Kampo, Sylvanus
    Wen, Qingping
    INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 2013, 31 (06) : 1313 - 1318
12345