Induction of pluripotent stem cells by defined factors is greatly improved by small-molecule compounds

被引：0
|
作者：
Danwei Huangfu
René Maehr
Wenjun Guo
Astrid Eijkelenboom
Melinda Snitow
Alice E Chen
Douglas A Melton
机构：
[1] Howard Hughes Medical Institute,Department of Stem Cell and Regenerative Biology
[2] Harvard Stem Cell Institute,undefined
[3] Harvard University,undefined
[4] Whitehead Institute for Biomedical Research,undefined
[5] Biomedical Sciences,undefined
[6] Utrecht University,undefined
来源：
Nature Biotechnology | 2008年 / 26卷
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摘要：
Existing methods for reprogramming somatic cells to 'induced pluripotent stem cells' are inefficient, with only a small fraction of the starting cell population becoming pluripotent. Working with mouse embryonic fibroblasts, Hunagfu et al. increase reprogramming efficiency by treatment with DNA methyltransferase and histone deacetylase inhibitors.
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页码：795 / 797
页数：2
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